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Institution: University of Yaound\u00e9 I<\/p>\n
Project Affiliation:<\/p>\n
Abstract<\/p>\n
BACKGROUND
\nTuberculosis is a major public health problem in the world, the number of deaths related to tuberculosis is estimated at 1.6 million people. Its association with HIV forms a deadly combination and is leading cause of morbidity and mortality.
\nOBJECTIVES
\nThe aim of this study was to determine the prevalence of HIV\/Tuberculosis co-infection and the evolution of liver enzymes in patients at the Yaounde Jamot Hospital.
\nMETHODOLOGY
\nWe carried out a cross-sectional study. Blood and sputum samples were collected from 362 peoples living with HIV over a period of six months (September 2017 to March 2018). For the determination of Mycobacterium Tuberculosis, bacteriological analyse was done and confirmed by a Polymerase Chain Reaction (PCR). The essay of liver markers were assayed by a kinetic method (Alanine Transaminase (ALT), Aspartate Transaminase (AST) and Alkaline Phosphatase (ALP)); a first blood sample was taken at recruitment and the second 3 months after the first sample. Data analysis was done using SPSS software 22.1. The statistical tests was performed were by Kruskal-Wallis and Mann Whitney U and all values of P\u22640.05 were considered to be statistically significant.<\/p>\n
RESULTS
\nThe female sex was predominantly represented 67, 1% (243) compared to the male sex 32, 9% (119) among the 362 patients recruited. We obtained 9.94% (36) of HIV\/Tuberculosis co-infection prevalence. A significant elevation of ALT and ALP were observed at the recruitment of patients in HIV\/Tuberculosis co-infected patients compared to HIV patients with (P <0.001) and (P=0.0001) respectively. After a period of 3 months, no significant parameter was observed.<\/p>\n
CONCLUSION
\nHIV associated to Tuberculosis negatively impacts the disease progression, which can be confirmed by increase of ALT and ALP. There is a necessity to control the disease progression through these. This co-infections remain a real public health problem due to the increase in co-morbidity among HIV patients, hence the need for careful and constant monitoring of this co-infection so as to ensure better management.<\/p>\n
NEXT STEPS
\nEstablish the link between co-infection and the rate of drug resistance.<\/p>\n
Key words: co-infections, HIV, Tuberculosis, liver markers<\/p>\n
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[\/vc_column_text][vc_basic_grid post_type=”page” max_items=”-1″ element_width=”3″ item=”5653″ grid_id=”vc_gid:1687253903872-50b0ec551d3fd61cf5f68ea85ad067be-7″ taxonomies=”211″][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"
[vc_row css=”.vc_custom_1671631128475{margin-top: 36px !important;}”][vc_column][vc_single_image image=”14189″ img_size=”medium” alignment=”center” style=”vc_box_rounded”][vc_column_text] Diane Kamdem [\u2026]<\/span><\/p>\n","protected":false},"author":2,"featured_media":13717,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":""},"categories":[],"tags":[211],"class_list":["post-14187","page","type-page","status-publish","has-post-thumbnail","hentry","tag-hiv_fellows"],"_links":{"self":[{"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/pages\/14187","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/comments?post=14187"}],"version-history":[{"count":2,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/pages\/14187\/revisions"}],"predecessor-version":[{"id":14190,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/pages\/14187\/revisions\/14190"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/media\/13717"}],"wp:attachment":[{"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/media?parent=14187"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/categories?post=14187"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/tags?post=14187"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}