[vc_row css=”.vc_custom_1671631128475{margin-top: 36px !important;}”][vc_column][vc_single_image image=”14253″ img_size=”medium” alignment=”center” style=”vc_box_rounded”][vc_column_text]<\/p>\n
[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n
Institution: Makerere University<\/p>\n
Project Affiliation: BRecA<\/p>\n
Abstract<\/p>\n
Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) developed into a global pandemic that affected the health of hundreds of millions worldwide (Mariam, 2022). In particular, SARS-CoV-2 infection in people with chronic human immune deficiency virus (HIV) infection is of concern, due to their already immunocompromised status. SARS-CoV-2-specific CD4 T cells have been shown to undergo robust activation and proliferation while CD8 T cells have been reported to undergo exhaustion in some hospitalized COVID-19 patients (Yang and Iwasaki 2021). Recent findings have shown that people living with HIV may be at increased risk of severe SARS-CoV-2 mediated disease complication due to functional impairment of the immune system and persistent inflammation, which can be ameliorated by antiretroviral therapy (Yang and Iwasaki 2021).
\nObjectives: 1) To compare the adaptive immune response to SARS-CoV-2 in HIV-positive individuals with those who are HIV-negative 2) To determine whether the severity of SARS-CoV-2 infection is affected by HIV coinfection. 3) To evaluate the role of CD4+ T cells in the immune response to SARS-CoV-2 in HIV-positive individuals.
\nMethodology: This study will use flow cytometry to analyze peripheral blood mononuclear cells (PBMCs) from COVID-19 patients. We shall analyze samples from participants coinfected with HIV and COVID-19 and participants with COVID-19 only. Specifically, we will immune profile CD4, CD8, and B cells for activation, proliferation, exhaustion, or memory states.<\/p>\n
[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n
[\/vc_column_text][vc_basic_grid post_type=”page” max_items=”-1″ element_width=”3″ item=”5653″ grid_id=”vc_gid:1687264710549-36179944aa73ea61eff0d7f9f1d68e67-8″ taxonomies=”211″][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"
[vc_row css=”.vc_custom_1671631128475{margin-top: 36px !important;}”][vc_column][vc_single_image image=”14253″ img_size=”medium” alignment=”center” style=”vc_box_rounded”][vc_column_text] Sharley Melissa [\u2026]<\/span><\/p>\n","protected":false},"author":2,"featured_media":13717,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":""},"categories":[],"tags":[211],"class_list":["post-14251","page","type-page","status-publish","has-post-thumbnail","hentry","tag-hiv_fellows"],"_links":{"self":[{"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/pages\/14251","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/comments?post=14251"}],"version-history":[{"count":2,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/pages\/14251\/revisions"}],"predecessor-version":[{"id":14254,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/pages\/14251\/revisions\/14254"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/media\/13717"}],"wp:attachment":[{"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/media?parent=14251"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/categories?post=14251"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/tags?post=14251"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}