{"id":7973,"date":"2020-08-05T17:37:38","date_gmt":"2020-08-05T15:37:38","guid":{"rendered":"https:\/\/h3africa.org\/?page_id=7973"},"modified":"2022-03-03T08:28:29","modified_gmt":"2022-03-03T06:28:29","slug":"sicklegenafrica","status":"publish","type":"page","link":"https:\/\/h3africa.org\/index.php\/sicklegenafrica\/","title":{"rendered":"Sickle Cell Disease Genomics Network of Africa (SickleGenAfrica)"},"content":{"rendered":"[vc_row css_animation=”fadeInDown”][vc_column][vc_column_text css_animation=”none” css=”.vc_custom_1590657817569{margin-top: 36px !important;}”]\n
H3Africa Collaborative Research Center<\/em><\/a><\/h6>\n

Sickle Cell Disease Genomics Network of Africa (SickleGenAfrica)<\/strong><\/h1>\n

The Goal: to understand how genetics influence the progression of Sickle Cell Disease (SCD) in Africans to inform novel management and treatment strategies.<\/h4>\n
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Project Leads<\/h3>\n[\/vc_column_text][vc_row_inner][vc_column_inner width=”1\/3″]
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Prof. Solomon Ofori-Acquah<\/h4>

Univeristy of Ghana, University of Pittsburgh<\/p>

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Prof. Gordon Awandare<\/h4>

University of Ghana<\/p>

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Prof. Julie Makani<\/h4>

Muhimbili University of Health and Allied Sciences<\/p>

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The Problem<\/h3>\nSickle Cell Disease (SCD) is one of the most common genetic diseases globally, but Africans are especially burdended by the disease: nearly 2% of births in sub-Sarahan Africa are affected by SCD. While solutions based largely on infection control have reduced the effects of the disease globally particularly among children, it is still difficult to predict, prevent and effectively manage the end-stage organ damage typical of this genetic disorder.\n

Project Strategy<\/h3>\n
    \n \t
  1. To develop prognostic markers of organ damage through the discovery of key genetic factors and mechanisms that influence the pathogenesis of SCD.<\/li>\n \t
  2. To build capacity and career pipelines in Africa to support translational and patient-centred research to advance the development of innovative therapy for SCD.<\/li>\n<\/ol>\n

    Outcomes to Date<\/h3>\nSickleGenAfrica\u2019s preliminary results have identified that quantitative differences in key hemolysis defense proteins influence the development of end-organ damage in SCD. The network is working to validate these results studying the largest global cohort of SCD patients, and animal models to learn more about their affects in the disease process. As this large-scale research project is in its infancy, the project is currently working to establish their core investigator networks and building infrastructure to support crucial laboratory and clinical work, which will enable it to make massive strides in understanding SCD in the coming years.\n\n\n

    Project Sites<\/h3>\n\n\n\n
    \n
    \"\"<\/a><\/figure>\n
    \n\n\n\nA: Ghana<\/strong>\nWest African Genetic Medicine Centre (WAGMC), University of Ghana, Accra. Kwame Nkrumah University of Science and Technology, Kumasi\n\nB: Nigeria<\/strong>\nBayero University, Kano. Aminu Kano Teaching Hospital, Kano. Institue of Human Virology Nigeria, Abuja. University of Abuja, Abuja. University of Lagos, Lagos\n\nC: Tanzania<\/strong>\nMuhumbili University of Health and Allied Sciences, Dar es Salaam\n\nNon-African Collaborators:<\/strong>\nUSA: University of Pittsburgh, Pittsburgh\n\n\n\n<\/div>\n<\/div>\n\n\n\n\n\n\n\n
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    Funding<\/h3>\n
    This work is supported by the U.S. National Institutes of Health (NIH), Office of the Director (OD), the National Heart, Lung and Blood Institute (NHLBI) and the National Human Genome Research Institute (NHGRI) grant number U54HL141011.<\/div>\n<\/div>\n[\/vc_column_text][vc_column_text]

    Additional Resources<\/h3>\n

    SickleGenAfrica Twitter<\/a><\/p>\n

    West African Genetic Medicine Center\u00a0<\/a><\/p>[\/vc_column_text][vc_row_inner][vc_column_inner width=”1\/3″][vc_btn title=”Project Publications (PubMed)” style=”custom” custom_background=”#c12000″ custom_text=”#ffffff” shape=”round” align=”center” link=”url:https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F%3Fterm%3DHL141011%255BGrant%2BNumber%255D|title:SickleGen%20PubMed%20Search|target:%20_blank|”][\/vc_column_inner][vc_column_inner width=”1\/3″][vc_btn title=”Scientific Description and Aims (NIH RePORT)” style=”custom” custom_background=”#c12000″ custom_text=”#ffffff” shape=”round” align=”center” link=”url:https%3A%2F%2Fprojectreporter.nih.gov%2Fproject_info_description.cfm%3Faid%3D9736473%26icde%3D51139349|title:SickleGenAfrica%20NIH%20RePORT|target:%20_blank|”][\/vc_column_inner][vc_column_inner width=”1\/3″][vc_btn title=”Download a PDF of this page” style=”custom” custom_background=”#c12000″ custom_text=”#ffffff” shape=”round” align=”center” link=”url:https%3A%2F%2Fh3africa.org%2Fwp-content%2Fuploads%2F2020%2F08%2FSickleGen_H3ACommDoc.pdf|title:SickleGen%20CommDoc|target:%20_blank|”][\/vc_column_inner][\/vc_row_inner][vc_column_text]\n

    Return to H3A Projects Page<\/a><\/em><\/p>\n[\/vc_column_text][\/vc_column][\/vc_row]","protected":false},"excerpt":{"rendered":"

    Sickle cell disease (SCD) is the commonest genetic disorder in the World. It is most prevalent in Africa. We have established SickleGenAfrica:Sickle Cell Disease Genomics Network of Africa to build capacity locally to enable African scientists study genomics of SCD on the continent<\/p>\n","protected":false},"author":16,"featured_media":5592,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":""},"categories":[7,4],"tags":[78],"class_list":["post-7973","page","type-page","status-publish","has-post-thumbnail","hentry","category-consortium-documents","category-projects","tag-nih-projects-collaborative-centers"],"_links":{"self":[{"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/pages\/7973","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/comments?post=7973"}],"version-history":[{"count":8,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/pages\/7973\/revisions"}],"predecessor-version":[{"id":12012,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/pages\/7973\/revisions\/12012"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/media\/5592"}],"wp:attachment":[{"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/media?parent=7973"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/categories?post=7973"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/tags?post=7973"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}