{"id":9742,"date":"2021-01-29T22:15:09","date_gmt":"2021-01-29T20:15:09","guid":{"rendered":"https:\/\/h3africa.org\/?page_id=9742"},"modified":"2021-01-29T22:24:08","modified_gmt":"2021-01-29T20:24:08","slug":"h3abionet","status":"publish","type":"page","link":"https:\/\/h3africa.org\/index.php\/h3abionet\/","title":{"rendered":"H3ABioNet"},"content":{"rendered":"[vc_row css_animation=”fadeInDown”][vc_column][vc_column_text css_animation=”none” css=”.vc_custom_1611951746613{margin-top: 36px !important;}”]
H3Africa Informatics Network<\/em><\/a><\/h6>\n

H3ABioNet<\/strong><\/h3>\n

The Goal: to develop bioinformatics capacity in Africa through training and support for data analysis, while also facilitating access to informatics infrastructure in the form of pipelines and tools for human, microbiome, and pathogen genomic data analysis.<\/h4>\n
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Project Leads<\/h3>\n[\/vc_column_text][vc_row_inner][vc_column_inner width=”1\/3″]
\"mulder\"<\/div><\/div>

Prof. Nicola Mulder<\/h4>

University of Cape Town<\/p>

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The Problem<\/h3>\n

Researchers working in the life sciences are generating data of increasing size and complexity due to modern research techniques. Interpreting this data is essential for understanding health and disease and developing solutions to improve African and global health. Considering this and also the lack of modern research infrastructure in Africa, there is an ever-increasing need to develop the human and physical capacity for bioinformatic research in Africa to enable the interpretation of valuable African genomics data.<\/p>\n

Project Strategy<\/h3>\n
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  1. Implement a pan-African informatics infrastructure<\/li>\n
  2. Develop an H3Africa Data Coordinating Center<\/li>\n
  3. Provide high quality informatics support to H3Africa<\/li>\n
  4. Enable and enhance innovative translational research<\/li>\n
  5. Establish outreach and sustainability plans<\/li>\n<\/ol>\n

    Outcomes to Date<\/h3>\n

    Training and Development<\/strong>
    \u2022 40 Courses\/workshops run, 29 face-to face, 2,256 people trained
    \u2022 Annual introductory and intermediate online courses
    \u2022 New bioinformatics degree programs developed in 4 African countries
    \u2022 15 accreditations in analysis of genomic data awarded<\/p>\n

    Enabling Genomic Medicine in Africa<\/strong>
    \u2022 Designed new genotyping chip for African populations
    \u2022 African genome reference panel for imputation
    \u2022 Genomic medicine curriculum designed and 225 nurses trained
    \u2022 Clinical data collection and phenotype harmonization support<\/p>\n

    Computing Infrastructure<\/strong>
    \u2022 17 computing facilities developed across 11 countries
    \u2022 3432 cores for data processing
    \u2022 1.2 petabytes available for storage and processing of African genomic data
    \u2022 4 genomic data analysis workflows developed and openly accessible<\/p>\n

    Data Management, Structure, and Transfer<\/strong>
    \u2022 14 African genomics datasets (135TB) stored in H3Africa archive
    \u2022 13 datasets QC’d and submitted to pubic repositories
    \u2022 Created the H3Africa Data Catalogue, which allows users to search for datasets and biospecimens of interest
    \u2022 77.3 terabytes of African genomic data transferred<\/p>\n

    <\/p>\n

    Project Sites<\/h3>\n
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    \"\"<\/a><\/figure>\n
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    H3ABioNet is a pan-African network consisting of 28 nodes across 16 African countries.<\/p>\n

    * = Lead Institution: <\/strong><\/p>\n

    South Africa: <\/strong>University of Cape Town<\/p>\n

    Non-African Collaborators<\/strong>:<\/p>\n

    USA: <\/strong>University of Illinois<\/p>\n<\/div>\n<\/div>\n

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    Funding<\/h3>\n
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    This work is supported by the U.S. National Institutes of Health (NIH) and the National Human Genome Research Institute (NHGRI) grant number U24HG006941.<\/p>\n<\/div>\n

    \u00a0<\/h3>\n

    Additional Resources<\/h3>\n

    H3ABioNet Website<\/a><\/p>\n<\/div>\n<\/div>[\/vc_column_text][vc_row_inner][vc_column_inner width=”1\/3″][vc_btn title=”Project Publications (PubMed)” style=”custom” custom_background=”#d32410″ custom_text=”#ffffff” shape=”round” align=”center” link=”url:https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F%3Fterm%3DHG006941%255BGrant%2BNumber%255D|title:Mulder%20PubMed%20Search|target:%20_blank|”][\/vc_column_inner][vc_column_inner width=”1\/3″][vc_btn title=”Scientific Description and Aims (NIH RePORT)” style=”custom” custom_background=”#d32410″ custom_text=”#ffffff” shape=”round” align=”center” link=”url:https%3A%2F%2Fprojectreporter.nih.gov%2Fproject_info_description.cfm%3Faid%3D9973107%26icde%3D53435082%26ddparam%3D%26ddvalue%3D%26ddsub%3D%26cr%3D1%26csb%3Ddefault%26cs%3DASC%26pball%3D|title:Mulder%20NIH%20RePORT|target:%20_blank|”][\/vc_column_inner][vc_column_inner width=”1\/3″][vc_btn title=”Download this page as PDF” style=”custom” custom_background=”#d32410″ custom_text=”#ffffff” shape=”round” align=”center” link=”url:https%3A%2F%2Fh3africa.org%2Fwp-content%2Fuploads%2F2021%2F01%2FMulder_H3ACommDoc-1.pdf|title:Mulder%20Comm%20Doc|target:%20_blank|”][\/vc_column_inner][\/vc_row_inner][vc_column_text]\n

    Return to H3Africa Projects Page<\/em><\/a><\/p>\n[\/vc_column_text][\/vc_column][\/vc_row]","protected":false},"excerpt":{"rendered":"

    AWI-Gen is the Africa Wits-INDEPTH partnership for Genomic Studies, an NIH funded and university supported Collaborative Center of the Human Heredity and Health in Africa<\/p>\n","protected":false},"author":16,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":""},"categories":[4],"tags":[33,78],"class_list":["post-9742","page","type-page","status-publish","hentry","category-projects","tag-collaborative-centers","tag-nih-projects-collaborative-centers"],"_links":{"self":[{"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/pages\/9742","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/comments?post=9742"}],"version-history":[{"count":4,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/pages\/9742\/revisions"}],"predecessor-version":[{"id":9768,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/pages\/9742\/revisions\/9768"}],"wp:attachment":[{"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/media?parent=9742"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/categories?post=9742"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/tags?post=9742"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}