{"id":13190,"date":"2022-09-23T13:55:36","date_gmt":"2022-09-23T11:55:36","guid":{"rendered":"https:\/\/h3africa.org\/?p=13190"},"modified":"2022-10-10T14:06:37","modified_gmt":"2022-10-10T12:06:37","slug":"how-africas-genetic-diversity-can-be-harnessed-to-close-the-continents-drug-and-treatment-gap","status":"publish","type":"post","link":"https:\/\/h3africa.org\/index.php\/2022\/09\/23\/how-africas-genetic-diversity-can-be-harnessed-to-close-the-continents-drug-and-treatment-gap\/","title":{"rendered":"How Africa\u2019s genetic diversity can be harnessed to close the continent\u2019s \u2018drug and treatment gap\u2019"},"content":{"rendered":"

[vc_row css=”.vc_custom_1665402960720{margin-top: 36px !important;}”][vc_column][vc_column_text]<\/p>\n

How Africa\u2019s genetic diversity can be harnessed to close the continent\u2019s \u2018drug and treatment gap\u2019<\/p>\n\n<\/h3>\n

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\"Credit:

Credit: Hugh Sitton\/Getty Images<\/p><\/div>\n

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“I have begged to just die.\u201d Those were the words of\u00a0Sadeh Sophia<\/a>, a sickle cell disease patient. Although living in the UK, she\u00a0suffers\u00a0from the genetic blood disorder that primarily targets\u00a0Africans, SCD globally affects 25 million people, mostly in equatorial countries across Africa, the Middle East and Asia. The World Health Organization reckons that circa\u00a0300, 000<\/a>\u00a0people are born with sickle cell disease. There is no cure.<\/p>\n

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\"Sadeh

Sadeh Sophia. Credit: My Friend Jen<\/p><\/div>\n

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Sub-Saharan Africa is the disease\u2019s\u00a0epicenter<\/a>. As many as 40% of the population in some African countries carry the trait.\u00a0About 1,000 children in Africa are born with SCD every day, and more than half will die before they reach 5 years old.<\/p>\n

Yet, the African genome, which could yield critical clues to the development of life-saving malaria drugs and medical treatments, has been vastly understudied. How can this be changed?<\/p>\n

Plagued by varying diseases<\/h4>\n

The diseases affecting Africans differ significantly in severity, scope and distribution from those that affect inhabitants of other regions. These are due to a variety of factors<\/a>, including genetics, economic development, political stability and even cultural norms. One example of such a disease is polio which was endemic<\/a> in Nigeria, Afghanistan, parts of Asia and most countries in Africa (presently, Pakistan and Afghanistan are the only polio-endemic countries).<\/p>\n

Malaria, transmitted by the Anopheles mosquito, which disproportionately affects<\/a> Africans, is largely linked to geographical location, hygiene conditions and economic development. It claims the life of a sub-Saharan African child every two minutes. The haemoglobinopathies and sickle cell trait (HbAS) confers protection from the lethal manifestation<\/a> of malaria. The vital aspect is the mutation that causes sickle cell disease which leads to a 90% risk reduction<\/a> of severe Plasmodium falciparum malaria across sub-Saharan Africa.<\/p>\n

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[vc_row css=”.vc_custom_1665402960720{margin-top: 36px !important;}”][vc_column][vc_column_text] How Africa\u2019s genetic diversity can be [\u2026]<\/span><\/p>\n","protected":false},"author":2,"featured_media":13191,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":""},"categories":[28],"tags":[182],"class_list":["post-13190","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-182"],"_links":{"self":[{"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/posts\/13190","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/comments?post=13190"}],"version-history":[{"count":2,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/posts\/13190\/revisions"}],"predecessor-version":[{"id":13193,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/posts\/13190\/revisions\/13193"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/media\/13191"}],"wp:attachment":[{"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/media?parent=13190"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/categories?post=13190"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/h3africa.org\/index.php\/wp-json\/wp\/v2\/tags?post=13190"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}