Meryem CHEBAK
University of Mohammed V-Rabat
I am Meryem CHEBAK Phd student in biology at the faculty of sciences at University Mohammed V of Rabat in Morocco, I wish to submit an abstract to your congress: African Microbiome Day: Showcasing microbiome research in Africa (Virtual) -, with a work that represents part of my thesis and it is submitted for publication.
Abstract
Introduction: Chlamydia pneumoniae is a respiratory pathogen associated with chronic inflammatory and its detection in human lung cancer suggests its involvement in cancerogenesis. The role of Chlamydia pneumoniae infection in the pathogenesis of Lung cancer, and its combined and interactive effect with various environmental factors in the development of Lung cancer disease were investigated in this case-control research.
Methods: The study comprised 42 lung cancer patients and 43 age- and sex-matched healthy controls. All participants provided demographics, Clinical, and Toxic behaviors datas, and a peripheral blood sample for testing, a Nested PCR was performed for C. pneumoniae DNA detection. Statistical analysis was performed using IBM®SPSS®software.
Results: Positive Nested PCR results for cases and controls were respectively 33.3% and 4.7%, there by significant difference between cases and controls infection was identified (p <0.05). Data analysis also showed that tobacco could act synergically with C. pneumoniae infection as a risk factor of lung cancer. In fact a significant difference between patients and controls was shown for tobacco and alcohol use (p < 0.05).
Conclusion: C. pneumoniae infection is potentially associated with primary Lung cancer in the Moroccan population and has combined effects with Tabaco consumption.