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Collaborative Centers

Project Description	PI Name(s)	Location
AWI-Gen 2: Genomic and Environmental Risk Factors for Cardiometabolic Disease in Africans	Michele Ramsay	Witwatersrand, Johannesburg, South Africa
Eyes of Africa: The Genetics of Blindness	Adeyinka Ashaye	Nigeria
Genomic Characterization and Surveillance of Microbial Threats in West Africa	Christian Happi	Nigeria
Genomic and Environmental Risk Factors for Cardiometabolic Disease in Africans	Michele Ramsay, Osman Sankoh	Witwatersrand, Johannesburg, South Africa
SickleGenAfrica: Sickle Cell Disease Genomics Network of Africa	Solomon Ofori-Acquah, Gordon Awandare, Julie Makani	Cameroon, Ghana, Nigeria and Tanzania
Center for Research on the Respiratory Microbiota of African Children (ReMAC)	Mark Nicol	South Africa, The Gambia, Malawi, USA
Stroke Investigative Research & Educational Network (SIREN)	Mayowa Owolabi, Bruce Ovbiagele	Nigeria & USA
Collaborative African Genomics Network (CAfGEN)	Mogomotsi Matshaba, Gabriel Anabwani, Moses Joloba, Adeodata Kekitiinwa, Graeme Mardon, Sununguko Wata Mpoloka, Oathokwa Nkomazana	Botswana & Uganda
H3Africa Kidney Disease Research Network	Dwomoa Adu, Akinlolu Ojo, Salako Babatunde	Ghana
African Collaborative Center for Microbiome and Genomics Research (ACCME)	Clement Adebamowo	Nigeria
Burden, spectrum and etiology of type 2 diabetes in sub-Saharan Africa	Prof. Ayesha Motala	South Africa
TrypanoGEN: An integrated approach to the identification of genetic determinants of susceptibility to trypanosomiasis	Enock Matovu	Uganda
The RHDGen Network: Genetics of rheumatic heart disease and molecular epidemiology of Streptococcus pyogenes pharyngitis	Bongani Mayosi	South Africa
TrypanoGEN +: The Genetic Determinants of Two Neglected Tropical Diseases	Enock Matovu	Uganda

Research Projects

Project Description	PI Name(s)	Location
The Genomics of Schizophrenia in the South African Xhosa People	Dr. Dan Stein, Prof. Raj S. Ramesar	South Africa
Transgenerational Effects of Maternal Stressors: Investigating the Role of Infant Gene Expression	Dr. Dan Stein, Dr. Nastassja Koen, Dr. Kerry Ressler, Dr. Aliza Wingo	South Africa
Reprogramming of the Trypanosoma brucei Epigenome during Human Infection: Opportunities for New Therapies	Dr. Enock Matovu, Hugh-George Patterton	Uganda, South Africa
The Nasopharyngeal Microbiome and Respiratory Disease in African Children	Prof. Mark Nicol	South Africa
Transgenerational Epigenomics of Trauma and PTSD in Rwanda	Dr. Leon Mutesa, Dr. Monica Uddin, Dr. Derek Wildman, Dr. Stefan Jansen	Rwanda
Immunoglobulin Gene Diversity in an African Population and Impact Antibody Function in HIV Infection	Prof. Lynn Morris	South Africa
Deciphering Developmental Disorders in Africa (DDD-Africa) – Evaluating Clinical Exome Sequencing in an African Setting	Dr. Zane Lombard	South Africa
Clinical and Genetic Studies of Hereditary Neurological Disorders in Mali	Prof. Guida Landoure	Mali
Host and Microbial Genetic Determinants of febrile illness in West Africa	Prof. Christian Happi	Nigeria
Systems Biology for Molecular Analysis of Tuberculosis in Ethiopia	Prof. Gobena Ameni	Ethiopia
Contribution of genetic variation to pharmacokinetic variability and toxicity in patients undergoing multi-drug tuberculosis treatment in Sub-Saharan Africa (RAFAgene)	Prof. Dissou Affolabi	Benin
African Female Breast Cancer Epidermiology (AFBRECANE) Study	Prof. Clement Adebamowo	Nigeria
Breast Milk Microbiota Influence on Infant Immunity and Growth (BEAMING)	Alash’le Abimiku	Nigeria
TB Genetics Network in Africa (TBGENAfrica)	Abraham Aseffa	Ethopia
Genetic interactions between human populations and malaria parasites in different environmental settings across Africa	Alfred Amambua Ngwa	The Gambia
Hearing Impairment Genetics Studies in Africa (HI-GENES Africa)	Prof. Ambroise Wonkam	South Africa

Ethical, Legal, and Society Issues (ELSI) Collaborative Centers

Project Description	PI Name(s)	Location
Developing Best Practices of Community Engagement for Genomics and Biobanking in Africa – CEBioGen	Ghansah Anita, Tindana Paulina	Ghana, Kenya, The Gambia, Nigeria, Tanzania and South Africa
Individual Findings in Genetic Research in Africa (IFGeneRA)	Prof. Ambroise Wonkam, Prof. Jantina de Vries	South Africa

Ethical, Legal, and Society Issues (ELSI) Research Projects

Project Description	PI Name(s)	Location
African Neurobiobank for Precision Stroke Medicine – (ELSI) Project	Akinyemi Rufus Olusola	Nigeria
Genetics and Genomic Research in Uganda: Towards Context Specific Ethics Guidelines	Ochieng Joseph	Uganda
Genomics Inheritance Legal and Social Issues	Dr Alice Matimba	Zimbabwe
Stigma in African genomics research on Schizophrenia and Rheumatic Heart Disease	Prof. Jantina de Vries	South Africa
Exploring Perspectives on Genomics and Sickle Cell Public Health Interventions	Prof. Ambroise Wonkam	South Africa
Enhancing Ethiopian youths’ literacy about the gene x environment contributions to health using the context of Podoconiosis	Prof. Getnet Tadele	Ethiopian
Indigenous Linguistic and Cultural Concepts of Heritability and Comprehension of Genomics Research in Africa (INDIGENE) Study	Prof. Clement Adebamowo	Nigeria
Ethical and Social issues in Informed Consent Processes in African Genomic Research	Dr. Erisa Sabakaki	Uganda

Biorepositories

Project Description	PI Name(s)	Location
Development of H3 Africa Biorepositories to Facilitate Studies on Biodiversity, Disease & Pharmacogenomics of African Populations	Dr. Akin Abayomi	South Africa
Establishment of an H3Africa Biorepository at Clinical Laboratory Services	Dr. Elizabeth Mayne, Prof. Ute Jentsch	South Africa
Integrated Biorepository of H3Africa Uganda – IBRH3AU	Prof. Moses Joloba	Uganda
IHVN H3 African Biorespository (I-HAB) Initiative	Dr. Alash’le G Abimiku	Nigeria

Bioinformatics Network

Project Description	PI Name(s)	Location
H3ABioNet: A Sustainable African Bioinformatics Network for H3Africa	Prof. Nicola Mulder	South Africa

Global Health Bioinformatics Research Training Program

Project Description	PI Name(s)	Location
Eastern Africa Network for Bioinformatics Training (EANBIT)	Daniel Masiga	Kenya
Nurturing Genomics and Bioinformatics Research Capacity in Africa (BRECA)	Dr. David Kateete, Dr. Daudi JJingo, Dr. Irving Jordan, Dr. Graeme Mardon	Uganda
West African Center of Excellence for Global Health Bioinformatics Research Training	Dr. Seydou Doumbia, Dr. Jian Li, Dr. Jeffrey Shaffer	Mali
West African Sustainable Leadership and Innovation Training in Bioinformatics Research (WASLITBRe)	Dr. Ezekiel Adebiyi, Dr. Peter Amoako-Yirenky, Dr. Seydou Doumbia	Nigeria

H3Africa Administrative Coordinating Centre

Project Description	PI Name(s)	Location
H3Africa Adminisrative Coordinating Centre: Enabling and Supporting Genomics and Health Research Capacity Building in Africa	Dr. Michelle Skelton	South Africa