H3Africa Publications for 2019


  1. Dissecting in silico Mutation Prediction of Variants in African Genomes: Challenges and Perspectives. Christian Domilongo Bope, Emile R Chimusa, Victoria Nembaware, Gaston K Mazandu, Jantina de Vries, Ambroise Wonkam. 2019 Jun 25;10:601. doi: 10.3389/fgene.2019.00601. eCollection 2019. PMID: 31293624 PMCID: PMC6603221 DOI: 10.3389/fgene.2019.00601 Free PMC article
  2. Noonan Syndrome in South Africa: Clinical and Molecular Profiles. Cedrik Tekendo-Ngongang, Gloudi Agenbag, Christian Domilongo Bope, Alina Izabela Esterhuizen, Ambroise Wonkam. 2019 Apr 16;10:333. doi: 10.3389/fgene.2019.00333. eCollection 2019.  PMID: 31057598 PMCID: PMC6477999 DOI: 10.3389/fgene.2019.00333
    Free PMC article
  3. GJB2 and GJB6 Mutations in Non-Syndromic Childhood Hearing Impairment in Ghana. Samuel M Adadey, Noluthando Manyisa, Khuthala Mnika, Carmen de Kock, Victoria Nembaware, Osbourne Quaye, Geoffrey K Amedofu, Gordon A Awandare, Ambroise Wonkam. Front Genet. 2019 Nov 26;10:1151. doi: 10.3389/fgene.2019.01151. eCollection 2019.  2019 Sep 18;10:841. doi: 10.3389/fgene.2019.00841. eCollection 2019.
    PMID: 31819744 Free PMC article.
  4. Association between IL1 gene polymorphism and human African trypanosomiasis in populations of sleeping sickness foci of southern Cameroon. Elvis Ofon, Harry Noyes, Vincent Ebo’o Eyanga, Flobert Njiokou, Mathurin Koffi, Pythagore Fogue, Christiane Hertz-Fowler, Annette MacLeod, Enock Matovu, Gustave Simo, TrypanoGEN Research Group, as members of The H3Africa Consortium. 2019 Mar 25;13(3):e0007283. doi: 10.1371/journal.pntd.0007283. eCollection 2019 Mar.  PMID: 30908482 PMCID: PMC6448947 DOI: 10.1371/journal.pntd.0007283 Free PMC article
  5. Association of APOL1 renal disease risk alleles with Trypanosoma brucei rhodesiense infection outcomes in the northern part of Malawi. Kelita Kamoto, Harry Noyes, Peter Nambala, Edward Senga, Janelisa Musaya, Benjamin Kumwenda, Bruno Bucheton, Annette Macleod, Anneli Cooper, Caroline Clucas, Christiane Herz-Fowler, Enock Matove, Arthur M Chiwaya, John E Chisi, TrypanoGEN Research Group as members of The H3Africa Consortium. 2019 Aug 14;13(8):e0007603. doi: 10.1371/journal.pntd.0007603. eCollection 2019 Aug. Free PMC article
  6. Cardiac expression of HMOX1 and PGF in sickle cell mice and haem-treated wild type mice dominates organ expression profiles via Nrf2 (Nfe2l2). Oluwabukola T Gbotosho, Samit Ghosh, Maria G Kapetanaki, Yu Lin, Frances Weidert, Grant C Bullock, Solomon F Ofori-Acquah, Gregory J Kato. 2019 Dec;187(5):666-675. doi: 10.1111/bjh.16129. Epub 2019 Aug 6.
    PMID: 31389006 DOI: 10.1111/bjh.16129
  7. Leveraging crowdsourcing to accelerate global health solutions. Sage Davis, Katrina Button-Simons, Taoufik Bensellak, Eren Mehmet Ahsen, Lisa Checkley, Gabriel J Foster, Xinzhuan Su, Ahmed Moussa, Darlington Mapiye, Sok Kean Khoo, Francois Nosten, Timothy J C Anderson, Katelyn Vendrely 1, Julie Bletz, Thomas Yu, Sumir Panji, Amel Ghouila, Nicola Mulder, Thea Norman, Steven Kern, Pablo Meyer, Gustavo Stolovitzky, Michael T Ferdig, Geoffrey H Siwo. 2019 Aug;37(8):848-850. doi: 10.1038/s41587-019-0180-5. PMID: 31324891 DOI: 10.1038/s41587-019-0180-5
  8. Machine-learning Prognostic Models from the 2014-16 Ebola Outbreak: Data-harmonization Challenges, Validation Strategies, and mHealth Applications. Andres Colubri, Mary-Anne Hartley, Matthew Siakoz, Vanessa Wolfman, August Felix, Tom Sesay, Jeffrey G Shaffer, Robert F Garry, Donald S Grant, Adam C Levine 6, Pardis C Sabeti.  2019 Jun 22;11:54-64. doi: 10.1016/j.eclinm.2019.06.003. eCollection May-Jun 2019.  PMID: 31312805 PMCID: PMC6610774 DOI: 10.1016/j.eclinm.2019.06.003 Free PMC article
  9. Classical Cardiovascular Risk Factors and HIV are Associated With Carotid Intima-Media Thickness in Adults From Sub-Saharan Africa: Findings From H3Africa AWI-Gen Study. Engelbert A Nonterah, Palwende R Boua, Kerstin Klipstein-Grobusch, Gershim Asiki, Lisa K Micklesfield, Godfred Agongo, Stuart A Ali, Felistas Mashinya, Herman Sorgho, Seydou Nakanabo-Diallo, Cornelius Debpuur, Catherine Kyobutungi, Marianne Alberts, Shane Norris, Stephen Tollman, Halidou Tinto, Cassandra C Soo, Freedom Mukomana, Scott Hazelhurst, Alisha N Wade, Kathleen Kahn, Abraham R Oduro, Diederick E Grobbee, Osman Sankoh, Michèle Ramsay, Michiel L Bots, Nigel J Crowther, as members and collaborators of AWI‐Gen and the H3Africa Consortium.  2019 Jul 16;8(14):e011506. doi: 10.1161/JAHA.118.011506. Epub 2019 Jul 13. PMID: 31304842 PMCID: PMC6662137 DOI: 10.1161/JAHA.118.011506 Free PMC article
  10. Dissecting in silico Mutation Prediction of Variants in African Genomes: Challenges and Perspectives. Christian Domilongo Bope, Emile R Chimusa, Victoria Nembaware, Gaston K Mazandu, Jantina de Vries, Ambroise Wonkam. 2019 Jun 25;10:601. doi: 10.3389/fgene.2019.00601. eCollection 2019. PMID: 31293624 PMCID: PMC6603221 DOI: 10.3389/fgene.2019.00601 Free PMC article
  11. Hydroxyurea-Induced miRNA Expression in Sickle Cell Disease Patients in Africa. Khuthala Mnika, Gaston K Mazandu, Mario Jonas, Gift D Pule, Emile R Chimusa, Neil A Hanchard, Ambroise Wonkam. 2019 May 28;10:509. doi: 10.3389/fgene.2019.00509. eCollection 2019. PMID: 31231425 PMCID: PMC6568309 DOI: 10.3389/fgene.2019.00509 Free PMC article
  12. Nasopharyngeal Carriage of Antimicrobial-Resistant Pneumococci in an Intensively Sampled South African Birth Cohort. Rendani I Manenzhe, Clinton Moodley, Shima M Abdulgader, F J Lourens Robberts, Heather J Zar, Mark P Nicol, Felix S Dube.  2019 Mar 27;10:610. doi: 10.3389/fmicb.2019.00610. eCollection 2019.PMID: 30972052 PMCID: PMC6446970 DOI: 10.3389/fmicb.2019.00610 Free PMC article
  13. C9orf72 repeat expansions in South Africans with amyotrophic lateral sclerosis. Melissa Nel, Gloudi M Agenbag, Franclo Henning, Helen M Cross, Alina Esterhuizen, Jeannine M Heckmann. 2019 Jun 15;401:51-54. doi: 10.1016/j.jns.2019.04.026. Epub 2019 Apr 17. PMID: 31009932 PMCID: PMC6556408 [Available on 2020-06-15] DOI: 10.1016/j.jns.2019.04.026 Free PMC article
  14. Molecular detection of Mycobacterium tuberculosis sensitivity to rifampicin and isoniazid in South Gondar Zone, northwest Ethiopia. Amir Alelign, Aboma Zewude, Temesgen Mohammed, Samuel Tolosa, Gobena Ameni, Beyene Petros. 2019 Apr 25;19(1):343. doi: 10.1186/s12879-019-3978-3. PMID: 31023267 PMCID: PMC6485134 DOI: 10.1186/s12879-019-3978-3 Free PMC article
  15. Expanding Research Capacity in Sub-Saharan Africa Through Informatics, Bioinformatics, and Data Science Training Programs in Mali. Jeffrey G Shaffer, Frances J Mather, Mamadou Wele, Jian Li, Cheick Oumar Tangara, Yaya Kassogue, Sudesh K Srivastav, Oumar Thiero, Mahamadou Diakite, Modibo Sangare, Djeneba Dabitao, Mahamoudou Toure, Abdoulaye A Djimde, Sekou Traore, Brehima Diakite, Mamadou B Coulibaly, Yaozhong Liu, Michelle Lacey, John J Lefante, Ousmane Koita, John S Schieffelin, Donald J Krogstad, Seydou O Doumbia. 2019 Apr 12;10:331. doi: 10.3389/fgene.2019.00331. eCollection 2019. PMID: 31031807 PMCID: PMC6473184 DOI: 10.3389/fgene.2019.00331 Free PMC article
  16. Gender differential in inclination to donate brain for research among Nigerians: the IBADAN Brain Bank Project.Rufus Akinyemi, Akin Ojagbemi, Joshua Akinyemi, Ayodeji Salami, Funmi Olopade, Temitope Farombi, Michael Nweke, Ezinne Uvere, Mayowa Aridegbe, James Balogun, Godwin Ogbole, Ayodele Jegede, Rajesh Kalaria, Adesola Ogunniyi, Mayowa Owolabi, Oyedunni Arulogun.  2019 Jun;20(2):297-306. doi: 10.1007/s10561-019-09769-4. Epub 2019 Apr 26.PMID: 31028517 PMCID: PMC6556418  DOI: 10.1007/s10561-019-09769-4 Free PMC article
  17. Structural variation of centromeric endogenous retroviruses in human populations and their impact on cutaneous T-cell lymphoma, Sézary syndrome, and HIV infection. Mark H Kaplan, Mark Kaminski, Judith M Estes, Scott D Gitlin, Joseph Zahn, James T Elder, Trilokraj Tejasvi, Elizabeth Gensterblum, Amr H Sawalha, Joseph Patrick McGowan, Michael H Dosik, Haner Direskeneli, Guher Saruhan Direskeneli, Sally N Adebamowo, Clement A Adebamowo, Mohammad Sajadi, Rafael Contreras-Galindo.  2019 May 2;12(1):58. doi: 10.1186/s12920-019-0505-8. PMID: 31046767 PMCID: PMC6498702 DOI: 10.1186/s12920-019-0505-8 Free PMC article
  18. Fahr’s syndrome with hyperparathyroidism revealed by seizures and proximal weaknessKékouta Dembélé, Lassana Cissé, Samba Djimdé, Youlouza Coulibaly, Salimata Diarra, Abdoulaye Yalcouyé, Boubacar Maiga, Cheick O Guinto, Guida Landouré, from The H3Africa Consortium. 2019 Apr 25;15:100192. doi: 10.1016/j.ensci.2019.100192. eCollection 2019 Jun.  PMID: 31080899 PMCID: PMC6504845 DOI: 10.1016/j.ensci.2019.100192 Free PMC article
  19. Influence of Socio-Economic and Psychosocial Profiles on the Human Breast Milk Bacteriome of South African Women.  Anna Ojo-Okunola, Shantelle Claassen-Weitz, Kilaza S Mwaikono, Sugnet Gardner-Lubbe, Dan J Stein, Heather J Zar, Mark P Nicol, Elloise du Toit. 2019 Jun 20;11(6):1390. doi: 10.3390/nu11061390. PMID: 31226873  Free PMC article
  20. A novel mutation in the GARS gene in a Malian family with Charcot-Marie-Tooth disease. Abdoulaye Yalcouyé, Seybou H Diallo, Thomas Coulibaly, Lassana Cissé, Salimata Diallo, Oumar Samassékou, Salimata Diarra, Dramane Coulibaly, Mohamed Keita, Cheick O Guinto, Kenneth Fischbeck, Guida Landouré, H3Africa Consortium. 2019 Jul;7(7):e00782. doi: 10.1002/mgg3.782. Epub 2019 Jun 7. PMID: 31173493 PMCID: PMC6625146 DOI: 10.1002/mgg3.782 Free PMC article
  21. How to use relevant data for maximal benefit with minimal risk: digital health data governance to protect vulnerable populations in low-income and middle-income countries. Nicki Tiffin, Asha George, Amnesty Elizabeth LeFevre.  2019 Apr 11;4(2):e001395. doi: 10.1136/bmjgh-2019-001395. eCollection 2019. PMID: 31139457 PMCID: PMC6509603 DOI: 10.1136/bmjgh-2019-001395 Free PMC article
  22. Role of genomics literacy in reducing the burden of common genetic diseases in Africa. Gerald Mboowa, Ivan Sserwadda.  2019 Jul;7(7):e00776. doi: 10.1002/mgg3.776. Epub 2019 May 26. PMID: 31131548 DOI: 10.1002/mgg3.776 Free PMC article
  23. Hereditary spastic paraplegia type 35 in a family from Mali.  Guida Landouré, Kékouta Dembélé, Lassana Cissé, Oumar Samassékou, Salimata Diarra, Abdoulaye Bocoum, Mohamede E Dembélé, Kenneth H Fischbeck, Cheick O Guinto, from The H3Africa Consortium. 2019 Jul;179(7):1122-1125. doi: 10.1002/ajmg.a.61179. Epub 2019 May 14. PMID: 31087769 PMCID: PMC6557683  DOI: 10.1002/ajmg.a.61179 Free PMC article
  24. Complimentary Methods for Multivariate Genome-Wide Association Study Identify New Susceptibility Genes for Blood Cell Traits. Segun Fatumo, Tommy Carstensen, Oyekanmi Nashiru, Deepti Gurdasani, Manjinder Sandhu, Pontiano Kaleebu. 2019 Apr 26;10:334. doi: 10.3389/fgene.2019.00334. eCollection 2019. PMID: 31080455 PMCID: PMC6497788 DOI: 10.3389/fgene.2019.00334 Free PMC article
  25. Sharing with Strangers: Governance Models for Borderless Genomic Research in a Territorial World.Eric T Juengst, Eric M Meslin. 2019;29(1):67-95. doi: 10.1353/ken.2019.0000. PMID: 31080178 DOI: 10.1353/ken.2019.0000
  26. Classical HLA alleles are associated with prevalent and persistent cervical high-risk HPV infection in African women. Sally N Adebamowo, Adebowale A Adeyemo, ACCME Research Group as part of the H3Africa Consortium. 2019 Sep;80(9):723-730. doi: 10.1016/j.humimm.2019.04.011. Epub 2019 May 6. PMID: 31072753 DOI: 10.1016/j.humimm.2019.04.011 Free PMC article
  27. Ten simple rules for organizing a webinar series.
    Faisal M Fadlelmola, Sumir Panji, Azza E Ahmed, Amel Ghouila, Wisdom A Akurugu, Jean-Baka Domelevo Entfellner, Oussema Souiai, Nicola Mulder, H3ABioNet Research working group as members of the H3Africa Consortium. 2019 Apr 1;15(4):e1006671. doi: 10.1371/journal.pcbi.1006671. eCollection 2019 Apr. PMID: 30933972 PMCID: PMC6443143 DOI: 10.1371/journal.pcbi.1006671 Free PMC article
  28. Differential Impact of Risk Factors on Stroke Occurrence Among Men Versus Women in West Africa.
    Albert Akpalu, Mulugeta Gebregziabher, Bruce Ovbiagele, Fred Sarfo, Henry Iheonye, Rufus Akinyemi, Onoja Akpa, Hemant K Tiwari, Donna Arnett, Kolawole Wahab, Daniel Lackland, Adeoye Abiodun, Godwin Ogbole, Carolyn Jenkins, Oyedunni Arulogun, Josephine Akpalu, Reginald Obiako, Paul Olowoyo, Michael Fawale, Morenikeji Komolafe, Godwin Osaigbovo, Yahaya Obiabo, Innocent Chukwuonye, Lukman Owolabi, Philip Adebay, Taofiki Sunmonu, Mayowa Owolabi . 2019 Apr;50(4):820-827. doi: 10.1161/STROKEAHA.118.022786. PMID: 30879432 PMCID: PMC6433514 DOI: 10.1161/STROKEAHA.118.022786 Free PMC article
  29. Longitudinal Population Dynamics of Staphylococcus aureus in the Nasopharynx During the First Year of Life.
    Shima M Abdulgader, Lourens Robberts, Jordache Ramjith, Polite M Nduru, Felix Dube, Sugnet Gardner-Lubbe 5, Heather J Zar, Mark P Nicol. 2019 Mar 15;10:198. doi: 10.3389/fgene.2019.00198. eCollection 2019. PMID: 30930937 PMCID: PMC6428701 DOI: 10.3389/fgene.2019.00198 Free PMC article
  30. C679X loss-of-function PCSK9 variant is associated with lower fasting glucose in black South African adolescents: Birth to Twenty Plus Cohort. Tinashe Chikowore, Venesa Sahibdeen, Liesl M Hendry, Shane A Norris, Julia H Goedecke, Lisa K Micklesfield, Zané Lombard. 2019 Feb 28;16:100186. doi: 10.1016/j.jcte.2019.100186. eCollection 2019 Jun. PMID: 30899674 PMCID: PMC6407309 DOI: 10.1016/j.jcte.2019.100186 Free PMC article
  31. Indoor air pollution and tobacco smoke exposure: impact on nasopharyngeal bacterial carriage in mothers and infants in an African birth cohort study. Aneesa Vanker, Polite M Nduru, Whitney Barnett, Felix S Dube, Peter D Sly, Robert P Gie, Mark P Nicol, Heather J Zar. 2019 Feb 4;5(1):00052-2018. doi: 10.1183/23120541.00052-2018. eCollection 2019 Feb. PMID: 30740462 PMCID: PMC6360211 DOI: 10.1183/23120541.00052-2018 Free PMC article
  32. Stroke, cerebrovascular diseases and vascular cognitive impairment in Africa. Rufus O Akinyemi, Mayowa O Owolabi, Masafumi Ihara, Albertino Damasceno, Adesola Ogunniyi, Catherine Dotchin, Stella-Maria Paddick, Julius Ogeng’o, Richard Walker, Raj N Kalaria. 2019 Feb;145:97-108. doi: 10.1016/j.brainresbull.2018.05.018. Epub 2018 May 25. PMID: 29807146 PMCID: PMC6252289 DOI: 10.1016/j.brainresbull.2018.05.018 Free PMC article
  33. Applying Mental Model Methods to Characterize Understanding of Gene-Environment Influences: The Case of Podoconiosis in Ethiopia. Caitlin G Allen, Colleen M McBride, Kibur Engdawork, Desta Ayode, Getnet Tadele. 2019;29(1):84-99. doi: 10.1080/09581596.2017.1409885. Epub 2017 Dec 6. PMID: 30853753 PMCID: PMC6405231 DOI: 10.1080/09581596.2017.1409885  Free PMC article
  34. Knowledge, attitudes and practices of West Africans on genetic studies of stroke: Evidence from the SIREN Study. 
    Rufus O Akinyemi, Fred S Sarfo, Joshua Akinyemi, Arti Singh, Matthew Onoja Akpa, Albert Akpalu, Lukman Owolabi, Abiodun M Adeoye, Reginald Obiako, Kolawole Wahab, Emmanuel Sanya, Morenikeji Komolafe, Godwin Ogbole, Michael Fawale, Philip Adebayo, Godwin Osaigbovo, Taofiki Sunmonu, Paul Olowoyo, Innocent Chukwuonye, Yahaya Obiabo, Olaleye Adeniji, Gregory Fakunle, Ezinne Melikam, Raelle Saulson, Joseph Yaria, Kelechi Uwanruochi, Phillip Ibinaiye, Ganiyu Adeniyi Amusa, Isah Suleiman Yahaya, Abdullahi Hamisu Dambatta, Mercy Faniyan, Peter Olowoniyi, Andrew Bock-Oruma, Odo Chidi Joseph, Ayodipupo Oguntade, Philip Kolo, Ruth Laryea, Sulaiman Lakoh, Ezinne Uvere, Temitope Farombi, Josephine Akpalu, Olalekan Oyinloye, Lambert Appiah, Benedict Calys-Tagoe, Vincent Shidali, Nasir Abdulkadir Tabari, Oladimeji Adebayo, Richard Efidi, Osi Adeleye, Dorcas Owusu, Luqman Ogunjimi, Olumayowa Aridegbe, Chidiebere Lucius Imoh, Taofeeq Sanni, Mulugeta Gebreziabher, Tiwari Hemant, Oyedunni Arulogun, Adesola Ogunniyi, Carolyn Jenkins, Mayowa Owolabi, Bruce Ovbiagele. 2019 Jan;14(1):69-79. doi: 10.1177/1747493018790059. Epub 2018 Jul 24. PMID: 30040054 DOI: 10.1177/1747493018790059