H3Africa Publications for 2021


  1. Genetic substructure and complex demographic history of South African Bantu speakers.  Sengupta D, Choudhury A, Fortes-Lima C, Aron S, Whitelaw G, Bostoen K, Gunnink H, Chousou-Polydouri N, Delius P, Tollman S, Gómez-Olivé FX, Norris S, Mashinya F, Alberts M; AWI-Gen Study; H3Africa Consortium, Hazelhurst S, Schlebusch CM, Ramsay M. Nat Commun. 2021 Apr 7;12(1):2080. doi: 10.1038/s41467-021-22207-y. PMID: 33828095; PMCID: PMC8027885.
  2. Genomics governance: advancing justice, fairness and equity through the lens of the African communitarian ethic of Ubuntu. Munung NS, de Vries J, Pratt B. Med Health Care Philos. 2021 Apr 2. doi: 10.1007/s11019-021-10012-9. Epub ahead of print. PMID: 33797712. 
  3. A scoping review of genetics and genomics research ethics policies and guidelines for Africa. Ali J, Cohn B, Mwaka E, Bollinger JM, Kwagala B, Barugahare J, Sewankambo NK, Ochieng J. BMC Med Ethics. 2021 Apr 2;22(1):39. doi: 10.1186/s12910-021-00611-9. PMID: 33810790; PMCID: PMC8017870.
  4. Tracking the emergence of new SARS-CoV-2 variants in South Africa. Happi AN, Ugwu CA, Happi CT. Nat Med. 2021 Mar;27(3):372-373. doi: 10.1038/s41591-021-01265-1. PMID: 33723453.
  5. H3ABioNet genomic medicine and microbiome data portals hackathon proceedings. Fadlelmola FM, Ghedira K, Hamdi Y, Hanachi M, Radouani F, Allali I, Kiran A, Zass L, Alsayed N, Fassatoui M, Samtal C, Ahmed S, Da Rocha J, Chaqsare S, Sallam RM, Chaouch M, Farahat M, Ssekagiri A, Parker Z, Adil M, Turkson M, Benchaalia A, Benkahla A, Panji S, Kassim S, Souiai O, Mulder N. Database (Oxford). 2021 Apr 17;2021:baab016. doi: 10.1093/database/baab016. PMID: 33864455; PMCID: PMC8052916.
  6. Human OMICs and Computational Biology Research in Africa: Current Challenges and Prospects.  Hamdi Y, Zass L, Othman H, Radouani F, Allali I, Hanachi M, Okeke CJ, Chaouch M, Tendwa MB, Samtal C, Mohamed Sallam R, Alsayed N, Turkson M, Ahmed S, Benkahla A, Romdhane L, Souiai O, Tastan Bishop Ö, Ghedira K, Mohamed Fadlelmola F, Mulder N, Kamal Kassim S. OMICS. 2021 Apr 1. doi: 10.1089/omi.2021.0004. Epub ahead of print. PMID: 33794662.
  7. Discovery and fine-mapping of kidney function loci in first genome-wide association study in Africans. Fatumo S, Chikowore T, Kalyesubula R, Nsubuga RN, Asiki G, Nashiru O, Seeley J, Crampin AC, Nitsch D, Smeeth L, Kaleebu P, Burgess S, Nyirenda M, Franceschini N, Morris AP, Tomlinson L, Newton R. Hum Mol Genet. 2021 Mar 30:ddab088. doi: 10.1093/hmg/ddab088. Epub ahead of print. PMID: 33783510.
  8. Unmapped exome reads implicate a role for Anelloviridae in childhood HIV-1 long-term non-progression. Mwesigwa S, Williams L, Retshabile G, Katagirya E, Mboowa G, Mlotshwa B, Kyobe S, Kateete DP, Wampande EM, Wayengera M, Mpoloka SW, Mirembe AN, Kasvosve I, Morapedi K, Kisitu GP, Kekitiinwa AR, Anabwani G, Joloba ML, Matovu E, Mulindwa J, Noyes H, Botha G; Collaborative African Genomics Network (CAfGEN); TrypanoGEN Research Group, Brown CW, Mardon G, Matshaba M, Hanchard NA. NPJ Genom Med. 2021 Mar 19;6(1):24. doi: 10.1038/s41525-021-00185-w. PMID: 33741997.
  9. The Independent Association of Prestroke Psychiatric Symptoms and Acute Phase Delirium with Poststroke Mortality at One Year in Nigeria. Ojagbemi A, Bello T, Owolabi M, Baiyewu O. J Stroke Cerebrovasc Dis. 2021 Apr;30(4):105622. doi: 10.1016/j.jstrokecerebrovasdis.2021.105622. Epub 2021 Jan 23. PMID: 33497933.
  10. Multimorbidity from Chronic Conditions among Adults in Urban Slums: The AWI-Gen Nairobi Site Study Findings. Mohamed SF, Haregu TN, Uthman OA, Khayeka-Wandabwa C, Muthuri SK, Asiki G, Kyobutungi C, Gill P. Glob Heart. 2021 Jan 20;16(1):6. doi: 10.5334/gh.771. PMID: 33598386; PMCID: PMC7824985.
  11. Negotiating political power and stigma around fragile X Syndrome in a rural village in Cameroon: A tale of a royal family and a community. Kengne Kamga K, Munung NS, Nguefack S, Wonkam A, De Vries J. Mol Genet Genomic Med. 2021 Feb 5:e1615. doi: 10.1002/mgg3.1615. Epub ahead of print. PMID: 33544459.
  12. Non-communicable diseases pandemic and precision medicine: Is Africa ready? Chikowore T, Kamiza AB, Oduaran OH, Machipisa T, Fatumo S. EBioMedicine. 2021 Feb 24;65:103260. doi: 10.1016/j.ebiom.2021.103260. Epub ahead of print. PMID: 33639396; PMCID: PMC7921515.
  13. The impact of psychopathology, social adversity and stress-relevant DNA methylation on prospective risk for post-traumatic stress: A machine learning approach. Wani AH, Aiello AE, Kim GS, Xue F, Martin CL, Ratanatharathorn A, Qu A, Koenen K, Galea S, Wildman DE, Uddin M. J Affect Disord. 2021 Mar 1;282:894-905. doi: 10.1016/j.jad.2020.12.076. Epub 2020 Dec 24. PMID: 33601733; PMCID: PMC7942200.
  14. Transcription-translation error: In-silico investigation of the structural and functional impact of deleterious single nucleotide polymorphisms in GULP1 gene. Soremekun OS, Ezenwa C, Soliman M, Chikowore T, Nashiru O, Fatumo S. Inform Med Unlocked. 2021;22:100503. doi: 10.1016/j.imu.2020.100503. Epub 2020 Dec 24. PMID: 33665355; PMCID: PMC7928429.
  15. Affordable method for quality DNA for genomic research in low to middle-income country research settings.
    Onyemata EJ, Jonathan E, Balogun O, Agala N, Ozumba PJ, Croxton T, Nadoma S, Anazodo T, Peters S, Beiswanger CM, Abimiku A. Anal Biochem. 2021 Feb 1;614:114023. doi: 10.1016/j.ab.2020.114023. Epub 2020 Nov 27. PMID: 33249001.
  16. Conceptual framework for establishing the African Stroke Organization. Akinyemi R, Sarfo F, Abd-Allah F, Ogun Y, Belo M, Francis P, Mateus MB, Bateman K, Naidoo P, Charway-Felli A, Akpalu A, Wahab K, Napon C, Arulogun O, Ebenezer AA, Ekeng G, Scola G, Hamzat K, Zimba S, Ossou-Nguiet PM, Ademokoya J, Adebayo P, Ayele BA, Vaz DC, Ogbole G, Barasukan P, Melifonwu R, Onwuekwe I, Belson S, Damasceno A, Okubadejo N, Njamnshi AK, Ogeng’o J, Walker RW, Diop AG, Ogunniyi A, Kalaria R, Sandercock P, Davis S, Brainin M, Ovbiagele B, Owolabi M. Int J Stroke. 2021 Jan;16(1):93-99. doi: 10.1177/1747493019897871. Epub 2020 Feb 6. PMID: 32026763.
  17. Factors associated with hypertension among stroke-free indigenous Africans: Findings from the SIREN study. Akpa OM, Okekunle AP, Ovbiagele B, Sarfo FS, Akinyemi RO, Akpalu A, Wahab KW, Komolafe M, Obiako R, Owolabi LF, Ogbole G, Fawale B, Fakunle A, Asaleye CM, Akisanya CO, Hamisu DA, Ogunjimi L, Adeoye A, Ogah O, Lackland D, Uvere EO, Faniyan MM, Asowata OJ, Adeleye O, Aridegbe M, Olunuga T, Yahaya IS, Olaleye A, Calys-Tagoe B, Owolabi MO; SIREN Study as part of the H3Africa Consortium. J Clin Hypertens (Greenwich). 2021 Jan 23. doi: 10.1111/jch.14183. Epub ahead of print. PMID: 33484599.
  18. Poor cardiovascular health is associated with subclinical atherosclerosis in apparently healthy sub-Saharan African populations: an H3Africa AWI-Gen study. Nonterah EA, Crowther NJ, Oduro A, Agongo G, Micklesfield LK, Boua PR, Choma SSR, Mohamed SF, Sorgho H, Tollman SM, Norris SA, Raal FJ, Grobbee DE, Ramsay M, Bots ML, Klipstein-Grobusch K; as part of the H3Africa AWI-Gen study. BMC Med. 2021 Feb 10;19(1):30. doi: 10.1186/s12916-021-01909-6. PMID: 33563289; PMCID: PMC7874493.
  19. Overview of The Human Heredity and Health in Africa Kidney Disease Research Network (H3A-KDRN). Dwomoa Adu, Akinlolu Ojo and the H3A-KDRN Investigators Kidney360 January 2021, 2 (1) 129-133; DOI: https://doi.org/10.34067/KID.0002592020.
  20. A pooled testing strategy for identifying SARS-CoV-2 at low prevalence. Mutesa L, Ndishimye P, Butera Y, Souopgui J, Uwineza A, Rutayisire R, Ndoricimpaye EL, Musoni E, Rujeni N, Nyatanyi T, Ntagwabira E, Semakula M, Musanabaganwa C, Nyamwasa D, Ndashimye M, Ujeneza E, Mwikarago IE, Muvunyi CM, Mazarati JB, Nsanzimana S, Turok N, Ndifon W. Nature. 2021 Jan;589(7841):276-280. doi: 10.1038/s41586-020-2885-5. Epub 2020 Oct 21. PMID: 33086375. 
  21. Short Communication: Genetic Variation in Human IL10 Proximal Promoter and Susceptibility to HIV-1 Infection in Mali, West Africa. Dabitao D, Dembele M, Urbanowski M, Kone B, Wague M, Coulibaly N, Sarro YDS, Baya B, Goita D, Dao S, Belson M, Klein SL, Achenbach C, Holl JL, Diakite M, Doumbia S, Bream JH, Bishai WR, Diallo S, Murphy RL. AIDS Res Hum Retroviruses. 2021 Jan;37(1):57-61. doi: 10.1089/AID.2020.0140. Epub 2020 Nov 23. PMID: 33045845. 
  22. Toward better governance of human genomic data. O’Doherty KC, Shabani M, Dove ES, Bentzen HB, Borry P, Burgess MM, Chalmers D, De Vries J, Eckstein L, Fullerton SM, Juengst E, Kato K, Kaye J, Knoppers BM, Koenig BA, Manson SM, McGrail KM, McGuire AL, Meslin EM, Nicol D, Prainsack B, Terry SF, Thorogood A, Burke W. Nat Genet. 2021 Jan;53(1):2-8. doi: 10.1038/s41588-020-00742-6. PMID: 33414545.
  23. Integrated molecular characterisation of the MAPK pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependencies. Sinkala M, Nkhoma P, Mulder N, Martin DP. Commun Biol. 2021 Jan 4;4(1):9. doi: 10.1038/s42003-020-01552-6. PMID: 33398072; PMCID: PMC7782843.
  24. Fine scale human genetic structure in three regions of Cameroon reveals episodic diversifying selection. Esoh KK, Apinjoh TO, Nyanjom SG, Wonkam A, Chimusa ER, Amenga-Etego L, Amambua-Ngwa A, Achidi EA.Sci Rep. 2021 Jan 13;11(1):1039. doi: 10.1038/s41598-020-79124-1. PMID: 33441574; PMCID: PMC7807043.
  25. Polymorphisms in Plasmodium falciparum dihydropteroate synthetase and dihydrofolate reductase genes in Nigerian children with uncomplicated malaria using high-resolution melting technique. Kayode AT, Ajogbasile FV, Akano K, Uwanibe JN, Oluniyi PE, Eromon PJ, Folarin OA, Sowunmi A, Wirth DF, Happi CT. Sci Rep. 2021 Jan 12;11(1):471. doi: 10.1038/s41598-020-80017-6. PMID: 33436791; PMCID: PMC7803958.
  26. Genomics and bioinformatics capacity in Africa: no continent is left behind. Mboowa G, Sserwadda I, Aruhomukama D. Genome. 2021 Jan 12:1-11. doi: 10.1139/gen-2020-0013. Epub ahead of print. PMID: 33433259.