H3Africa Publications for 2021


  1. Friedreich ataxia in a family from Mali, West Africa/Friedreich ataxia in a Malian family. Cissé, C.A.K., Cissé, L., Ba, H.O., Samassékou, O., Simaga, A., Taméga, A., Diarra, S., Diallo, S.H., Coulibaly, T., Diallo, S., Yalcouyé, A., Maiga, A.B., Keita, M., Fischbeck, K.H., Traoré, S.F., Guinto, C.O., Landouré, G., 2021. Clinical Case Reports 9.. doi:10.1002/ccr3.4065
  2. Candidate gene family-based and case-control studies of susceptibility to high Schistosoma mansoni worm burden in African children: a protocol [version 1; peer review: awaiting peer review]. Nyangiri OA, Edwige SA, Koffi M et al. AAS Open Res 2021,4:36 https://doi.org/10.12688/aasopenres.13203.1)
  3. Genomic investigation of atypical malaria cases in Kanel, northern Senegal. Sy M, Badiane AS, Deme AB, Gaye A, Ndiaye T, Fall FB, Siddle KJ, Dieye B, Ndiaye YD, Diallo MA, Diongue K, Seck MC, Ndiaye IM, Cissé M, Gueye AB, Sène D, Dieye Y, Souané T, MacInnis B, Volkman SK, Wirth DF, Ndiaye D. Malar J. 2021 Feb 19;20(1):103. doi: 10.1186/s12936-021-03637-x. PMID: 33608006; PMCID: PMC7893743.
  4. The trans-ancestral genomic architecture of glycemic traits. Chen J, Spracklen CN, Marenne G, et al. Nat Genet. 2021 Jun;53(6):840-860. doi: 10.1038/s41588-021-00852-9. Epub 2021 May 31. PMID: 34059833; PMCID: PMC7610958.
  5. Genomic investigation of a dengue virus outbreak in Thiès, Senegal, in 2018. Gaye A, Ndiaye T, Sy M, Deme AB, Thiaw AB, Sene A, Ndiaye C, Diedhiou Y, Mbaye AM, Ndiaye I, Tomkins-Tinch C, Gomis JF, Badiane AS, MacInnis B, Park DJ, Ndiaye M, Sy N, Sabeti PC, Siddle KJ, Ndiaye D. Sci Rep. 2021 May 14;11(1):10321. doi: 10.1038/s41598-021-89070-1. PMID: 33990632; PMCID: PMC8121849.
  6. A Longitudinal Study of the Epidemiology of Seasonal Coronaviruses in an African Birth Cohort. Nicol MP, MacGinty R, Workman L, Stadler JAM, Myer L, Allen V, Ah Tow Edries L, Zar HJ. J Pediatric Infect Dis Soc. 2021 May 28;10(5):607-614. doi: 10.1093/jpids/piaa168. PMID: 33528016; PMCID: PMC7928775.
  7. Prevalence and socio-demographic correlates of tobacco and alcohol use in four sub-Saharan African countries: a cross-sectional study of middle-aged adults. Boua PR, Soo CC, Debpuur C, Maposa I, Nkoana S, Mohamed SF, Choma S, Oduro A, Asiki G, Micklesfield LK, Gómez-Olivé FX, Sorgho H, Mall S, Ramsay M; as members of AWI-Gen and the H3Africa Consortium. BMC Public Health. 2021 Jun 12;21(1):1126. doi: 10.1186/s12889-021-11084-1. PMID: 34118914; PMCID: PMC8196437.
  8. Fine scale human genetic structure in three regions of Cameroon reveals episodic diversifying selection. Esoh KK, Apinjoh TO, Nyanjom SG, Wonkam A, Chimusa ER, Amenga-Etego L, Amambua-Ngwa A, Achidi EA. Sci Rep. 2021 Jan 13;11(1):1039. doi: 10.1038/s41598-020-79124-1. PMID: 33441574; PMCID: PMC7807043.
  9. Association of Novel Locus With Rheumatic Heart Disease in Black African Individuals: Findings From the RHDGen Study. Machipisa T, Chong M, Muhamed B, Chishala C, Shaboodien G, Pandie S, de Vries J, Laing N, Joachim A, Daniels R, Ntsekhe M, Hugo-Hamman CT, Gitura B, Ogendo S, Lwabi P, Okello E, Damasceno A, Novela C, Mocumbi AO, Madeira G, Musuku J, Mtaja A, ElSayed A, Elhassan HHM, Bode-Thomas F, Okeahialam BN, Zühlke LJ, Mulder N, Ramesar R, Lesosky M, Parks T, Cordell HJ, Keavney B, Engel ME, Paré G.  JAMA Cardiol. 2021 Jun 9:e211627. doi: 10.1001/jamacardio.2021.1627. Epub ahead of print. PMID: 34106200; PMCID: PMC8190704.
  10. African genetic diversity and adaptation inform a precision medicine agenda. Pereira L, Mutesa L, Tindana P, Ramsay M. Nat Rev Genet. 2021 May;22(5):284-306. doi: 10.1038/s41576-020-00306-8. Epub 2021 Jan 11. PMID: 33432191.
  11. Affordable method for quality DNA for genomic research in low to middle-income country research settings. Onyemata EJ, Jonathan E, Balogun O, Agala N, Ozumba PJ, Croxton T, Nadoma S, Anazodo T, Peters S, Beiswanger CM, Abimiku A. Anal Biochem. 2021 Feb 1;614:114023. doi: 10.1016/j.ab.2020.114023. Epub 2020 Nov 27. PMID: 33249001.
  12. Bantu-speaker migration and admixture in southern Africa. Choudhury A, Sengupta D, Ramsay M, Schlebusch C. Hum Mol Genet. 2021 Apr 26;30(R1):R56-R63. doi: 10.1093/hmg/ddaa274. PMID: 33367711; PMCID: PMC8117461.
  13. Promoting diversity and inclusion in neuroscience and neuroethics. Matshabane OP. EBioMedicine. 2021 May;67:103359. doi: 10.1016/j.ebiom.2021.103359. Epub 2021 May 6. PMID: 33965871; PMCID: PMC8114114.
  14. Ending a diagnostic odyssey-The first case of Takenouchi-Kosaki syndrome in an African patient. Flynn K, Feben C, Lamola L, Carstens N, Krause A, Lombard Z; for DDD‐Africa as members of the H3Africa Consortium. Clin Case Rep. 2021 Mar 2;9(4):2144-2148. doi: 10.1002/ccr3.3966. PMID: 33936654; PMCID: PMC8077267.
  15. The benefit sharing vision of H3Africa. Dauda B, Joffe S. Dev World Bioeth. 2018 Jun;18(2):165-170. doi: 10.1111/dewb.12185. Epub 2018 Feb 15. PMID: 29446211.
  16. Using a multiple-delivery-mode training approach to develop local capacity and infrastructure for advanced bioinformatics in Africa. Ras V, Botha G, Aron S, Lennard K, Allali I, Claassen-Weitz S, Mwaikono KS, Kennedy D, Holmes JR, Rendon G, Panji S, Fields CJ, Mulder N. PLoS Comput Biol. 2021 Feb 25;17(2):e1008640. doi: 10.1371/journal.pcbi.1008640. PMID: 33630830; PMCID: PMC7906323.
  17. Community engagement and feedback of results in the H3Africa AWI-Gen project: Experiences from the Navrongo Demographic and Health Surveillance site in Northern Ghana. Agongo G, Debpuur C, Amenga-Etego L, Nonterah EA, Kaburise MB, Oduro A, Ramsay M, Tindana P. AAS Open Res. 2021 Mar 19;4:15. doi: 10.12688/aasopenres.13081.1. PMID: 33959702; PMCID: PMC8063542.
  18. Adiposity Phenotypes and Subclinical Atherosclerosis in Adults from Sub-Saharan Africa: An H3Africa AWI-Gen Study. Nonterah EA, Bots ML, Oduro A, Agongo G, Soo CC, Micklesfield LK, Mashinya F, Boua PR, Mohamed SF, Wade AN, Kyobutungi C, Tinto H, Norris SA, Tollman SM, Ramsay M, Grobbee DE, Klipstein-Grobusch K, Crowther NJ; AWI–Gen and the H3Africa Consortium. Glob Heart. 2021 Mar 19;16(1):19. doi: 10.5334/gh.863. PMID: 33833943; PMCID: PMC7977036.
  19. Genetic substructure and complex demographic history of South African Bantu speakers.  Sengupta D, Choudhury A, Fortes-Lima C, Aron S, Whitelaw G, Bostoen K, Gunnink H, Chousou-Polydouri N, Delius P, Tollman S, Gómez-Olivé FX, Norris S, Mashinya F, Alberts M; AWI-Gen Study; H3Africa Consortium, Hazelhurst S, Schlebusch CM, Ramsay M. Nat Commun. 2021 Apr 7;12(1):2080. doi: 10.1038/s41467-021-22207-y. PMID: 33828095; PMCID: PMC8027885.
  20. Genomics governance: advancing justice, fairness and equity through the lens of the African communitarian ethic of Ubuntu. Munung NS, de Vries J, Pratt B. Med Health Care Philos. 2021 Apr 2. doi: 10.1007/s11019-021-10012-9. Epub ahead of print. PMID: 33797712. 
  21. A scoping review of genetics and genomics research ethics policies and guidelines for Africa. Ali J, Cohn B, Mwaka E, Bollinger JM, Kwagala B, Barugahare J, Sewankambo NK, Ochieng J. BMC Med Ethics. 2021 Apr 2;22(1):39. doi: 10.1186/s12910-021-00611-9. PMID: 33810790; PMCID: PMC8017870.
  22. Tracking the emergence of new SARS-CoV-2 variants in South Africa. Happi AN, Ugwu CA, Happi CT. Nat Med. 2021 Mar;27(3):372-373. doi: 10.1038/s41591-021-01265-1. PMID: 33723453.
  23. H3ABioNet genomic medicine and microbiome data portals hackathon proceedings. Fadlelmola FM, Ghedira K, Hamdi Y, Hanachi M, Radouani F, Allali I, Kiran A, Zass L, Alsayed N, Fassatoui M, Samtal C, Ahmed S, Da Rocha J, Chaqsare S, Sallam RM, Chaouch M, Farahat M, Ssekagiri A, Parker Z, Adil M, Turkson M, Benchaalia A, Benkahla A, Panji S, Kassim S, Souiai O, Mulder N. Database (Oxford). 2021 Apr 17;2021:baab016. doi: 10.1093/database/baab016. PMID: 33864455; PMCID: PMC8052916.
  24. Human OMICs and Computational Biology Research in Africa: Current Challenges and Prospects.  Hamdi Y, Zass L, Othman H, Radouani F, Allali I, Hanachi M, Okeke CJ, Chaouch M, Tendwa MB, Samtal C, Mohamed Sallam R, Alsayed N, Turkson M, Ahmed S, Benkahla A, Romdhane L, Souiai O, Tastan Bishop Ö, Ghedira K, Mohamed Fadlelmola F, Mulder N, Kamal Kassim S. OMICS. 2021 Apr 1. doi: 10.1089/omi.2021.0004. Epub ahead of print. PMID: 33794662.
  25. Discovery and fine-mapping of kidney function loci in first genome-wide association study in Africans. Fatumo S, Chikowore T, Kalyesubula R, Nsubuga RN, Asiki G, Nashiru O, Seeley J, Crampin AC, Nitsch D, Smeeth L, Kaleebu P, Burgess S, Nyirenda M, Franceschini N, Morris AP, Tomlinson L, Newton R. Hum Mol Genet. 2021 Mar 30:ddab088. doi: 10.1093/hmg/ddab088. Epub ahead of print. PMID: 33783510.
  26. Unmapped exome reads implicate a role for Anelloviridae in childhood HIV-1 long-term non-progression. Mwesigwa S, Williams L, Retshabile G, Katagirya E, Mboowa G, Mlotshwa B, Kyobe S, Kateete DP, Wampande EM, Wayengera M, Mpoloka SW, Mirembe AN, Kasvosve I, Morapedi K, Kisitu GP, Kekitiinwa AR, Anabwani G, Joloba ML, Matovu E, Mulindwa J, Noyes H, Botha G; Collaborative African Genomics Network (CAfGEN); TrypanoGEN Research Group, Brown CW, Mardon G, Matshaba M, Hanchard NA. NPJ Genom Med. 2021 Mar 19;6(1):24. doi: 10.1038/s41525-021-00185-w. PMID: 33741997.
  27. The Independent Association of Prestroke Psychiatric Symptoms and Acute Phase Delirium with Poststroke Mortality at One Year in Nigeria. Ojagbemi A, Bello T, Owolabi M, Baiyewu O. J Stroke Cerebrovasc Dis. 2021 Apr;30(4):105622. doi: 10.1016/j.jstrokecerebrovasdis.2021.105622. Epub 2021 Jan 23. PMID: 33497933.
  28. Multimorbidity from Chronic Conditions among Adults in Urban Slums: The AWI-Gen Nairobi Site Study Findings. Mohamed SF, Haregu TN, Uthman OA, Khayeka-Wandabwa C, Muthuri SK, Asiki G, Kyobutungi C, Gill P. Glob Heart. 2021 Jan 20;16(1):6. doi: 10.5334/gh.771. PMID: 33598386; PMCID: PMC7824985.
  29. Negotiating political power and stigma around fragile X Syndrome in a rural village in Cameroon: A tale of a royal family and a community. Kengne Kamga K, Munung NS, Nguefack S, Wonkam A, De Vries J. Mol Genet Genomic Med. 2021 Feb 5:e1615. doi: 10.1002/mgg3.1615. Epub ahead of print. PMID: 33544459.
  30. Non-communicable diseases pandemic and precision medicine: Is Africa ready? Chikowore T, Kamiza AB, Oduaran OH, Machipisa T, Fatumo S. EBioMedicine. 2021 Feb 24;65:103260. doi: 10.1016/j.ebiom.2021.103260. Epub ahead of print. PMID: 33639396; PMCID: PMC7921515.
  31. The impact of psychopathology, social adversity and stress-relevant DNA methylation on prospective risk for post-traumatic stress: A machine learning approach. Wani AH, Aiello AE, Kim GS, Xue F, Martin CL, Ratanatharathorn A, Qu A, Koenen K, Galea S, Wildman DE, Uddin M. J Affect Disord. 2021 Mar 1;282:894-905. doi: 10.1016/j.jad.2020.12.076. Epub 2020 Dec 24. PMID: 33601733; PMCID: PMC7942200.
  32. Transcription-translation error: In-silico investigation of the structural and functional impact of deleterious single nucleotide polymorphisms in GULP1 gene. Soremekun OS, Ezenwa C, Soliman M, Chikowore T, Nashiru O, Fatumo S. Inform Med Unlocked. 2021;22:100503. doi: 10.1016/j.imu.2020.100503. Epub 2020 Dec 24. PMID: 33665355; PMCID: PMC7928429.
  33. Affordable method for quality DNA for genomic research in low to middle-income country research settings.
    Onyemata EJ, Jonathan E, Balogun O, Agala N, Ozumba PJ, Croxton T, Nadoma S, Anazodo T, Peters S, Beiswanger CM, Abimiku A. Anal Biochem. 2021 Feb 1;614:114023. doi: 10.1016/j.ab.2020.114023. Epub 2020 Nov 27. PMID: 33249001.
  34. Conceptual framework for establishing the African Stroke Organization. Akinyemi R, Sarfo F, Abd-Allah F, Ogun Y, Belo M, Francis P, Mateus MB, Bateman K, Naidoo P, Charway-Felli A, Akpalu A, Wahab K, Napon C, Arulogun O, Ebenezer AA, Ekeng G, Scola G, Hamzat K, Zimba S, Ossou-Nguiet PM, Ademokoya J, Adebayo P, Ayele BA, Vaz DC, Ogbole G, Barasukan P, Melifonwu R, Onwuekwe I, Belson S, Damasceno A, Okubadejo N, Njamnshi AK, Ogeng’o J, Walker RW, Diop AG, Ogunniyi A, Kalaria R, Sandercock P, Davis S, Brainin M, Ovbiagele B, Owolabi M. Int J Stroke. 2021 Jan;16(1):93-99. doi: 10.1177/1747493019897871. Epub 2020 Feb 6. PMID: 32026763.
  35. Factors associated with hypertension among stroke-free indigenous Africans: Findings from the SIREN study. Akpa OM, Okekunle AP, Ovbiagele B, Sarfo FS, Akinyemi RO, Akpalu A, Wahab KW, Komolafe M, Obiako R, Owolabi LF, Ogbole G, Fawale B, Fakunle A, Asaleye CM, Akisanya CO, Hamisu DA, Ogunjimi L, Adeoye A, Ogah O, Lackland D, Uvere EO, Faniyan MM, Asowata OJ, Adeleye O, Aridegbe M, Olunuga T, Yahaya IS, Olaleye A, Calys-Tagoe B, Owolabi MO; SIREN Study as part of the H3Africa Consortium. J Clin Hypertens (Greenwich). 2021 Jan 23. doi: 10.1111/jch.14183. Epub ahead of print. PMID: 33484599.
  36. Poor cardiovascular health is associated with subclinical atherosclerosis in apparently healthy sub-Saharan African populations: an H3Africa AWI-Gen study. Nonterah EA, Crowther NJ, Oduro A, Agongo G, Micklesfield LK, Boua PR, Choma SSR, Mohamed SF, Sorgho H, Tollman SM, Norris SA, Raal FJ, Grobbee DE, Ramsay M, Bots ML, Klipstein-Grobusch K; as part of the H3Africa AWI-Gen study. BMC Med. 2021 Feb 10;19(1):30. doi: 10.1186/s12916-021-01909-6. PMID: 33563289; PMCID: PMC7874493.
  37. Overview of The Human Heredity and Health in Africa Kidney Disease Research Network (H3A-KDRN). Dwomoa Adu, Akinlolu Ojo and the H3A-KDRN Investigators Kidney360 January 2021, 2 (1) 129-133; DOI: https://doi.org/10.34067/KID.0002592020.
  38. A pooled testing strategy for identifying SARS-CoV-2 at low prevalence. Mutesa L, Ndishimye P, Butera Y, Souopgui J, Uwineza A, Rutayisire R, Ndoricimpaye EL, Musoni E, Rujeni N, Nyatanyi T, Ntagwabira E, Semakula M, Musanabaganwa C, Nyamwasa D, Ndashimye M, Ujeneza E, Mwikarago IE, Muvunyi CM, Mazarati JB, Nsanzimana S, Turok N, Ndifon W. Nature. 2021 Jan;589(7841):276-280. doi: 10.1038/s41586-020-2885-5. Epub 2020 Oct 21. PMID: 33086375. 
  39. Short Communication: Genetic Variation in Human IL10 Proximal Promoter and Susceptibility to HIV-1 Infection in Mali, West Africa. Dabitao D, Dembele M, Urbanowski M, Kone B, Wague M, Coulibaly N, Sarro YDS, Baya B, Goita D, Dao S, Belson M, Klein SL, Achenbach C, Holl JL, Diakite M, Doumbia S, Bream JH, Bishai WR, Diallo S, Murphy RL. AIDS Res Hum Retroviruses. 2021 Jan;37(1):57-61. doi: 10.1089/AID.2020.0140. Epub 2020 Nov 23. PMID: 33045845. 
  40. Toward better governance of human genomic data. O’Doherty KC, Shabani M, Dove ES, Bentzen HB, Borry P, Burgess MM, Chalmers D, De Vries J, Eckstein L, Fullerton SM, Juengst E, Kato K, Kaye J, Knoppers BM, Koenig BA, Manson SM, McGrail KM, McGuire AL, Meslin EM, Nicol D, Prainsack B, Terry SF, Thorogood A, Burke W. Nat Genet. 2021 Jan;53(1):2-8. doi: 10.1038/s41588-020-00742-6. PMID: 33414545.
  41. Integrated molecular characterisation of the MAPK pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependencies. Sinkala M, Nkhoma P, Mulder N, Martin DP. Commun Biol. 2021 Jan 4;4(1):9. doi: 10.1038/s42003-020-01552-6. PMID: 33398072; PMCID: PMC7782843.
  42. Fine scale human genetic structure in three regions of Cameroon reveals episodic diversifying selection. Esoh KK, Apinjoh TO, Nyanjom SG, Wonkam A, Chimusa ER, Amenga-Etego L, Amambua-Ngwa A, Achidi EA.Sci Rep. 2021 Jan 13;11(1):1039. doi: 10.1038/s41598-020-79124-1. PMID: 33441574; PMCID: PMC7807043.
  43. Polymorphisms in Plasmodium falciparum dihydropteroate synthetase and dihydrofolate reductase genes in Nigerian children with uncomplicated malaria using high-resolution melting technique. Kayode AT, Ajogbasile FV, Akano K, Uwanibe JN, Oluniyi PE, Eromon PJ, Folarin OA, Sowunmi A, Wirth DF, Happi CT. Sci Rep. 2021 Jan 12;11(1):471. doi: 10.1038/s41598-020-80017-6. PMID: 33436791; PMCID: PMC7803958.
  44. Genomics and bioinformatics capacity in Africa: no continent is left behind. Mboowa G, Sserwadda I, Aruhomukama D. Genome. 2021 Jan 12:1-11. doi: 10.1139/gen-2020-0013. Epub ahead of print. PMID: 33433259.