Ida Guiateu Tamo
H3Africa PI: Djuidje Ngounoue Marceline
Institution: University of Yaoundé I
Hepatitis C remains a public health issue worldwide. HCV (hepatitis C virus) shares some common routes of transmission with the Human Immunodeficiency Virus (HIV), and can lead to many complications. The study objective was to analyse and compare biochemical markers and socio-demographic data, in people living with HIV/AIDS and HIV/HCV co-infected identified in Yaoundé Central Hospital, Cameroon
From November 2015 to February 2016, the serum of 75 patients who tested positive for HIV at Yaoundé Central Hospital. Socio-demographic data were collected and some biochemical parameters (ALT, AST, -GT, LAP, Bilirubin) were analysed. The data was entered and analysed using SPSS version 22.1. Statistical analysis was performed using Student-t-test. The statistical significance was set at the threshold p ≤ 0.05.
In HIV mono-infected, The mean age was 50.39 ± 11.43 and lower than that of HIV/HCV coinfected (58.57 ± 3.74), and the predominant sex was female. The result show a significant increase of -GT (P <0.0001) and Total Bilirubin (P = 0.015) in HIV/HCV co-infected patients compared to HIV mono-infected patients. The infection is more common in widows/widowers, 33.3% with a predominance of secondary level, 28 (37.3%) in HIV mono-infected and 6 (8.0%) in HIV-HCV co-infected. High proportions of patients with LAP enzymatic activities higher than normal values are observed within the population.
The infection is high among women and affects all social classes and remains a problem in society with variation of some markers.
Next steps : determine the electropheretic profile in disease control