H3Africa Research Project

Breast Milk Microbiota Influence on Infant Immunity and Growth (BEAMING)

The Goal: To understand how breast milk affects a child’s gut microbiome, and the effects this has on the child’s immune system, response to vaccinations, and overall development.

Project Leads

Dr. Alash'le Abimiku

Institute of Human Virology


Dr. Clive Gray

University of Cape Town


Dr. Jonathan Blackburn

University of Cape Town


The Problem

While modern HIV prevention and treatment have dramatically reduced the transmission of HIV from infected mothers to their infants, these children (also known as HIV exposed uninfected, or HEU) face much higher mortality rates than their HIV unexposed (HU) counterparts. Furthermore, HEU children have been shown to have different responses to vaccines than HU children. Finally, while it is known that breastfeeding these HEU children can improve their immune systems, it is unclear how this mechanism of protection operates, indicating that there is much to learn about the effect of breastmilk on the immune systems of HEU children.

Project Strategy

  1. To compare the microbes of breastmilk of mothers and gut microbiomes of infants (in both HIV+/HEU and HIV-/HU pairs) to understand the role of the breastmilk in child development.
  2. To investigate the immune response of vaccines in HEU and HU children, specifically monitoring how they affect microbial composition.
  3. To investigate the association between the genes of HEU children how their immune systems respond to vaccines.

Outcomes to Date

While the BEAMING project is in its infancy, the group has begun to lay the foundation upon which they will conduct their research in the coming years, establishing their core personnel and infrastructures that will efficiently enable them to execute out their strategy. Additionally, the project has made promising first steps into their key research aims with preliminary results indicating an effect of breastmilk microbiota on the gut microbiome of newborns. In the coming years, BEAMING will continue to make headway in answering their research questions, which could inform and influence public health policy in Africa and globally for generations to follow.

Project Sites

A: Nigeria
Institute of Human Virology

B: South Africa
University of Cape Town

Funding

This work is supported by the U.S. National Institutes of Health (NIH), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Human Genome Research Institute (NHGRI) grant number U01HD094658.

Additional Resources

October 8, 2020

Breast Milk Microbiota Influence on Infant Immunity and Growth (BEAMING)

Understanding microbial shifts and how they affect vaccine response is central to this study. We will determine if gut microbial communities associated with breastfeeding in the HEU infant follows the same successional trajectory as HU controls and resolve the differences at functional level. How the continuous conditioning of the infant gut by the microbiota from the breast milk affects the infant microbiome and subsequent
October 7, 2020

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