H3Africa Collaborative Research Center

Genomic Characterization and Surveillance of Microbial Threats in West Africa

The Goal: to develop innovative genomic tools and strategies that will reduce the devastating impact of viral diseases, like Ebola and Lassa fever, on West African populations.

Project Leads

Dr. Christian Happi

Redeemer’s Univeristy


Dr. Pardis Sabeti

Broad Institute


Dr. Donald Grant

Kenema Government Hospital


Dr. Daouda Ndiaye

Université Cheikh Anta Diop de Dakar


Dr. Peter Okokhere

Irrua Specialist Teaching Hospital


Dr. Robert Garry

Tulane University


The Problem

Fevers of unknown origins are incredibly difficult to diagnose, due to their vast diversity and complexity. As a result, recent viral outbreaks have had a devastating impact on African populations, highlighting vulnerabilities in African public health systems. Tools to enable the rapid, accurate diagnosis and analysis of patient samples were often not readily available in the areas affected by outbreaks, making it more difficult to reduce morbidity and mortality during recent epidemics.

Project Strategy

  1. Utilize modern genomic technologies to better understand the nature and extent of fevers of unknown origins, including viral infections in West Africa.
  2. Develop robust and cost-effective field diagnostics to swiftly and accurately capture the prevalence of these viruses in the population.
  3. Use genomic and immunological data to characterize the pathogen-host interaction and enhance clinical care.

Outcomes to Date

Viral Research

  • Established modern genomics hubs in Nigeria, Senegal, and Sierra Leone that have the ability to identify and analyze unknown circulating viruses.
  • Used these hubs to rapidly characterize and track emergent viruses and outbreaks in West Africa including Lassa Virus (Nigeria, Sierra Leone), Yellow Fever (Nigeria), Dengue Virus (Sengal). This brisk action enabled local governments to implement containment strategies and enhanced patient care to effectively reduce the public health impact.
  • Helped contain and characterize the Ebola outbreak in Nigeria.

Technology Development

  • Developed a novel variation of SHERLOCK, a low-cost genomics test, to rapidly identify three types of fever at the bedside, reducing the standard of care diagnostic time; deployed during the recent Lassa outbreak in Nigeria.
  • Developed additional genomics tests to enable rapid identification of Ebola virus, Zika virus, Chikungunya virus, Yellow fever virus, Dengue virus, and West Nile virus, performed trainings, and deployed in Nigeria, Sierra Leone, and Senegal.

Project Sites

A: Nigeria
Redeemer’s University &
Irrua Specialist Teaching Hospital

B: Senegal
Université Cheikh Anta Diop

C: Sierra Leone
Kenema Government Hospital

Non-African Collaborators:

USA: Broad Institute, Harvard University, & Tulane University

Funding

This work is supported by the U.S. National Institutes of Health (NIH), Office of the Director (OD), the National Institute of Allergy and Infectious Diseases (NIAID), and the National Human Genome Research Institute (NHGRI) grant number U54HG007480.
August 10, 2020

Genomic Characterization and Surveillance of Microbial Threats in West Africa

Overall Recent viral outbreaks in West Africa, specifically the 2013-16 Ebola Virus Outbreak, shed light on the many limitations of current surveillance and diagnostics in the region’s public health systems. Tools for rapid, accurate
August 5, 2020

Sickle Cell Disease Genomics Network of Africa (SickleGenAfrica)

Sickle cell disease (SCD) is the commonest genetic disorder in the World. It is most prevalent in Africa. We have established SickleGenAfrica:Sickle Cell Disease Genomics Network of Africa to build capacity locally to enable African scientists study genomics of SCD on the continent
August 4, 2020

Collaborative African Genomics Network (CAfGEN)

Advanced genetic and genomic technologies promise to transform our understanding and approach to human health and disease. Such genomic analyses are now common in Western populations of European descent.
August 4, 2020

Africa Wits-INDEPTH Partnership for Genomic Research (AWI-Gen)

AWI-Gen is the Africa Wits-INDEPTH partnership for Genomic Studies, an NIH funded and university supported Collaborative Center of the Human Heredity and Health in Africa
June 21, 2019

Prof Oyedunni Arulogun

June 21, 2019

Dr Rufus Akinyemi

March 25, 2019

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The over-arching aim of this network is to improve the health of people living in some of the poorest countries in the world that carry a disproportionate burden of infectious diseases. Despite their importance, the study of many tropical diseases has lagged behind that of diseases of developed countries.
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