Events – Page 2

Twelfth H3Africa Consortium Meeting

VENUE: Kigali Convention Centre (KCC), Radisson Blu Hotel & Remera College of Medicine and Health Sciences Kigali Rwanda

Sunday 16 September

H3Africa Fellows Day/Environmental Health in Africa Workshop/Poster Sessions

Monday 17 September

H3Africa Principal Investigators /Working Group Sessions/Genomic Medicine & Translational Research/Poster Sessions

Tuesday 18 September

H3Africa Principal Investigators/ Sustainability Panel Discussion/Working Group Sessions/Poster Sessions

Wednesday 19 September

Joint African Society of Human Genetics and H3Africa

Thursday 20 September

African Society of Human Genetics

Friday 21 September

African Society of Human Genetics

Saturday 22 September

Next Generation Sequencing Workshop

Analysis for Monogenic Disease in Africa Populations

Sunday 23 September

Next Generation Sequencing Workshop

Analysis for Monogenic Disease in Africa Populations

Gallery

H3Africa 12th Consortium Meeting Photos

H3Africa Fellows Research Day Sunday 16 September

7:30	Bus leaves Radisson Blu Hotel
8:00 – 8:30	Registration
8:30 – 9:10	Welcoming address by Prof Leon Mutesa, Associate Professor of Human Genetics, Director of Center for Human Genetics, College of Medicine and Health Sciences, University of Rwanda
SESSION 1: Eukaryotes Chair—
09:10 – 10:00	KEYNOTE speaker:
10:00 – 10:10	Ahouty Bernardin	HLA-G 14-bp Ins associated with decreased risk of the human sleeping sickness within Côte d’Ivoire population
10:10 – 10:20	Windingoudi Justin Kabore	Beyond GWAS: eQTL to assign function to SNP
10:20 – 10:30	Kolapo Oyebola	Assessing human genetic polymorphisms and varying efficacy of artemisinin-based combination treatment of malaria in Nigeria
10:30 – 10:40	Diane Mutumwinka	PiggyBac-based screening identified BEM4 as a suppressor to rescue growth defects in och1-disrupted yeast cells
10:40 – 10:50	Yasmine Ochi	Characterization of Inter-species Protein Interactions: Use of SLiM motifs to infer interactions between Plasmodium falciparum and its hosts
10:50 – 11:00	Questions and discussion
11:00 – 11:30	MORNING TEA/COFFEE BREAK and POSTER SESSION
SESSION 2: Bacteria and viruses Chair—
11:30 – 12:20	KEYNOTE: Prof Babatunde Salako, Director-General/CEO, Nigerian Institute of Medical Research (NIMR)
12:20 – 12:30	Benard Kulohoma	Peripheral blood RNA gene expression in children with pneumococcal meningitis: a prospective case control study.
12:30 – 12:40	Busisiwe Mlotshwa	Characterization of active TB disease establishment in HIV/ TB co-infected children in sub-Saharan Africa using integrated genomic analyses
12:40 – 12:50	Erdaw Tachbele	Prevalence of Virological Failure and Acquired Drug Resistance Mutations detected by Deep Sequencing in virologic failures among Antiretroviral Treatment Experienced HIV-1 patients in South Omo, Ethiopia.
12:30 – 12:45	Felix Sizwe Dube	Characterisation of lineage and locus-specific variations associated with of pneumococcal carriage dynamics post PCV-13 implementation in an African birth cohort: The Drakenstein Child Health Study
12:45– 12:55	Edgar Kigozi	Practicability of Next Generation Sequencing in a Low income African Setting with A focus on Whole Genome Sequencing of Multi-drug Resistant M. tuberculosis isolates from Uganda
12:55 – 13:05	Marion Amujal	Nonsynonymous genetic variants in chemokines and their cognate ligands important in HIV/AIDS disease progression in a Ugandan paediatric population attending Baylor College of Medicine children’s Foundation Clinical Centers of Excellence.
13:05 – 13:15	San James	MicroGWAS: A fast, reliable and user-friendly web-based tool for Genome-wide analyses of microbe data
13:15 – 13:30	Questions and Discussion
13:30 – 14:15	LUNCH and POSTER SESSION
SESSION 3: Non-Infectious Diseases Chair—
14:15 – 14:25	Segun Fatumo	Analysis of multiple related phenotypes in a sub-Saharan Africa population genome-wide association study
14:25 – 14:35	Edmond Wonkam	Identifying new genes and variants involved in Hearing Impairment (HI) in Cameroon, using Next Generation Sequence (NGS) data
14:35 – 14:45	Ernestine Kubi	Sickle Cell Trait and Chronic Kidney Disease
14:45 – 14:55	Gerrye Mubungu Lumbono	Frequency of minor anomalies in Congolese newborn
14:55 – 15:05	Lord Gowans	Missense Mutations in KIF4A Alter Dental Morphogenesis Resulting in X-linked Taurodontism, Microdontia and Dens-Invaginatus
15:05 – 15:15	Oladimeji Adebayo	Genomic and environmental determinants of LVH among West Africans with stroke. Insight from Stroke Investigative Research and Education Network (SIREN) study
15:15 – 15:25	Gerald Mboowa	Charting the Genetic Architecture of Clinically Relevant Variations from the Collaborative African Genomics Network (CAfGEN) Exomes Using ClinVar Database
15:25 – 15:35	Paul Katongole	Role of gut microbiota in the pathogenesis of Prostate cancer in Sub-Saharan Africa
15:35 – 15:50	Questions and Discussion
15:50 – 16:15	Afternoon TEA/Coffee Break
Closing, announcement of awards and vote of thanks: Chair—
16:15 – 16:25		Vote of thanks
16:25 – 16:45		Announcement of H3Africa Fellows’ Day Presentation Prize Winners
16:45 – 17:00	Bus leaves to Radisson Blu Hotel
18:30	PIZZA DINNER at Filini KCC

Environmental Health in Africa: Opportunities to Expand Research Capacity in the H3Africa Consortium Sunday 16 September

Time	Theme	Activities and Speakers
7:00	Registration	AD 12 Foyer
8:00 – 8:15	Welcome: Gwen Collman, Director of NIEHS Division of Extramural Research and Training Charge of the workshop: Kim McAllister and Bonnie Joubert, NIEHS
8:15 – 8:30	History and Directions of the H3Africa Consortium Michelle Skelton, University of Cape Town
8:30 – 9:00	Global Environmental and Occupational (GEO) Health	The Michigan-West Africa GEOHealth Hub: Environmental Exposures due to Informal E-waste Recycling Activities and the Health of Workers Julius Fobil, University of Ghana Exposure focus: electronic waste
9:00 – 9:30	Global Environmental and Occupational (GEO) Health	East Africa GEOHealth Hub (Ethiopia): Ambient Air Pollution Exposure and Child Respiratory Health in Ethiopia, Uganda, Rwanda, and Kenya Abera Kumie, Addis Ababa University Exposure focus: ambient air pollution
9:30 – 9:45		Break
9:45 – 10:15	Biomarkers and Mechanisms	Mycotoxin Biomarkers and Children’s Health in Africa: Translation of Basic Research to Public Health Prevention Joshua Smith, Johns Hopkins University Exposure focus: mold
10:15 – 10:45		Heavy Metal Exposure and Cardiometabolic Phenotypes Cathrine Hoyo, North Carolina State University Exposure focus: metals
10:45 – 11:15		Toxicodietary and Genetic Determinants of Susceptibility to Neurodegeneration in the Congo Daniel Tshala Katumbay, Oregon Health Sciences University Exposure focus: nutrition
11:15 – 13:00		Lunch and Poster Presentations
13:00 – 13:30	Environmental Exposures and Infectious Disease	Indoor Residual Spraying for Malaria Control and Child Development in the South African VHEMBE birth cohort. Jonathan Chevrier, McGill University, ISEE Africa Chapter Exposure focus: pesticides
13:30 – 14:00	Environmental Exposures and Infectious Disease	Trace Elements and Risk of Severe Malaria and Neurodevelopmental Impairment Chandy John, Indiana University Exposure focus: biomarkers of exposure and inflammation
14:00 – 14:15		Break
14:15 – 16:45	Panel Discussion Chairs: Mark Nicol, University of Cape Town Michele Ramsay, Wits University Panelists: Kiros Berhane, University of Southern California Brenda Eskenazi, University of California, Berkeley Adrie Steyn, Africa Health Research Institute
16:45	Closing remarks: Gwen Collman, NIEHS

H3Africa Consortium Meeting Monday 17 September 2018

7:00	Registration MH 1 Foyer
	AD 11 (Break Out Room)			AD7 (Boardroom)
8:00-8:45	H3Africa Principal Investigators			Independent Expert Committee (IEC)
8:45-9:30				IEC & Funders
9:30-9:45	Tea/Coffee Poster Session MH 1 Foyer (15 min)
	Working Group Session I
	AD 7	AD 10		AD11		AD1
9:45-11:00	Phenotype Harmonization Chair: TBA Rapporteur: Robin Mason & Karen Lacourciere	Education & Coordinated Training WG Chairs: Oumar Samassekou & Reginald Obiako Rapporteur: Laura Povlich & Maria Giovanni		Biorepository WG Chair: Elizabeth Mayne Rapporteur: Gabriel Batzli		Environmental Health Chairs: TBA Rapporteur: Bonnie Joubert and Kimberly McAllister
	Plenary Session I MH 1 Chair: Barry Bloom
11:00-12:50	Genomic Medicine & Translational Research Facilitators: Nicky Mulder & Jenniffer Maroa
12:50-13:50	Lunch (Auditorium Club Level 1 KCC) & Poster Sessions MH1 Foyer (60 min)
	H3Africa PI Presentations Session I MH1 Chair: Rex Chisholm
13:50-14:10	Project: H3Africa Administrative Coordinating Centre: Enabling and Supporting Genomics and Health Research Capacity Building in Africa Title: H3ACC Updates Presenter & PI: Michelle Skelton Presentation: 15 min Q&A 5 min
14:10-14:30	Project: Transgenerational Epigenomics of Trauma and PTSD in Rwanda Presenter & PI: Leon Mutesa Presentation: 18 min Q&A 2 min
14:30-14:50	Project: AWI-Gen Phase 2: Genomic and environmental risk factors for cardiometabolic disease in Africans Title: Genetic and environmental contributions to cardiometabolic diseases and related traits in Africans: AWI-Gen coming to fruition Presenter & PI: Michele Ramsay Presentation: 18 min Q&A 2 min
14:50-15:10	Project: Collaborative African Genomics Network (CAfGEN) Title: Collaborative African Genomics Network (CAfGEN) Study Updates Presenter & PI: Mogomotsi Matshaba Presentation: 18 min Q&A 2min
15:10-15:30	Project: H3ABioNet: a sustainable African Bioinformatics Network for H3Africa Title: H3ABioNet resources for H3Africa Presenter & PI: Nicola Mulder Presentation: 18 min Q&A: 2 min
15:30-15:50	Project: RHDGen: The Genetics of Rheumatic Heart Disease Network Title: Tribute to Bongani Mayosi & Update from RHDGen Presenters: Mark Engel & Babu Muhamed PI: Bongani Mayosi Presentation: 18 min Q&A 2 min
15:50-16:05	Tea & Poster Session MH1 Foyer (15 min)
	H3Africa PI Presentations Session II Biorepositories MH1 Chair: Rex Chisholm
16:05-16:30	Project: Integrated Biorepository of H3Africa Uganda – IBRH3AU PI: Moses Joloba
	Project: IHVN H3Africa Biorepository (I-HAB) Initiative PI: Alash’le Abimiku
	Project: Establishment of an H3Africa Biorepository at Clinical Laboratory Services PI: Elizabeth Mayne
	Working Group Session II
	AD 7		AD 10		AD 11		AD 1
16:30-18:00	Outreach & Communications Chair: TBA Rapporteurs: Barbara Sina & Deborah Ndlovu		Genome Analysis/ GAPW Sub Group Chairs: Zane Lombard; Adebowale Adeyemo & Neil Hanchard Rapporteur: Charles Rotimi & Gabriel Batzli		HIV/AIDS Chairs: Mogomotsi Matshaba & Francesc Xavier Gomez-Olive Rapporteur: Sudha Srinivasan & Megan Hoffman		Sustainability Chairs; Raj Ramesar & Dwomoa Adu Rapporteur: Jennifer Troyer, Mark Guyer & Audrey Duncanson
	Working Group Report Back Session I MH1 Chair: Philip Awadalla
	Working Group				Presenter
18:00-18:40	Education & Coordinated Training				Oumar Samassekou
	Environmental Health				Gwen Collman
	Biorepository				Elizabeth Mayne
	Phenotype Harmonization				TBA
	Discussion & Feedback
19:00	Drinks Reception (The Larder/Hotel Pool Area/Rooftop Bar KCC) TBC Weather Dependent
19:30	Dinner at Filini Restaurant

H3Africa Consortium Meeting Tuesday 18 September 2018

8:00	Registration MH 1 Foyer
	Working Group Session III
	AD 6 (Boardroom)	AD 7 (Boardroom)	AD 10			AD 11	AD 1	MH 1
8:00-8:30	Data & Biospecimen Access Committee (DBAC) Chair: Akin Abayomi Rapporteur: Jenniffer Maroa		CVD Chair: Akinlolu Ojo & Sally Adebamowo Rapporteur: Jennifer Troyer			Ethics & Community Engagement WG Chair: Aminu Yakubu & Paulina Tindana Rapporteur: Ebony Madden & Katherine Littler	Study Coordinators Chairs: Emmanuel Nasinghe & Keofentse Mathuba Rapporteur: Robin Mason & Karen Lacourciere	Rare Disease Chair: Zane Lombard Rapporteur: Megan Hoffman
8:30-9:30		DBAC WG Chair: Nicola Mulder Rapporteur: Audrey Duncanson
	Plenary Session II MH 1 Chairs: Raj Ramesar & Dwomoa Adu
9:30-11:00	Sustainability & Outreach Mini Presentations/Panel Discussion Glaudina Loots; Peter Goodhand; Hans Hagen; Isayvani Naicker
11:00-11:15	Tea/Coffee Poster Session MH 1 Foyer (15 min)
	AD 10			AD 11
11:15-12:15	Data Submission Session Facilitator: Ayton Meintjes			H3Africa PI & DBAC
	Plenary Session III MH 1 Chair: Philip Awadalla
12:15-13:15	H3Africa Data & Biospecimen Catalogue Presenters: Hocine Bendou & Nicola Mulder
13:15-14:15	Lunch (Auditorium Club Level 1 KCC) (60 min)
	H3Africa PI Presentations Session III MH1 Chair: Charmaine Royal
14:15-14:35	Project: West African Sustainable Leadership and Innovation Training in Bioinformatics Research (WASLITBRE) Presenter: Ezekiel Adebiyi PI: Ezekiel Adebiyi, Peter Amoako-Yirenky, Seydou Doumbia Presentation: 18 min Q&A: 2min
14:35-14:55	Project: West African Center of Excellence for Global Health Bioinformatics Research Training Title: “A Bioinformatics Training Program in Mali: Approach, Perspective, and Sustainability” Presenter: Jeffrey Shaffer PI: Seydou Doumbia, Jian Li, Jeffrey Shaffer Presentation: 13 min Q&A: 2min
14:55-15:15	Project & Presentation Title: Nurturing Genomics and Bioinformatics Research Capacity in Africa (BRecA) Presenter: Daudi Jjingo PI: David Kateete, Daudi JJingo, Irving Jordan, Graeme Mardon Presentation: 18 min Q&A: 2min
15:15-15:35	Project: Eastern Africa Network for Bioinformatics Training Presenter: Daniel Masiga PI: Daniel Masiga Presentation: 18 min Q&A: 2min
15:35-15:45	Tea/Coffee Break (10 min)
	Plenary Session IV MH1 Chair: Barry Bloom & Charmaine Royal
15:45-16:00	FAIR Data Presenter: Nicola Mulder
	Working Group Report Back Session II MH1 Chair: Barry Bloom & Charmaine Royal
						Presenter
16:00 -17:00	Ethics & CE WG					Aminu Yakubu & Paulina Tindana
	Study Coordinators					Emmanuel Nasinghe
	Genome Analysis WG/GAPW Sub Group					Adebowale Adeyemo & Neil Hanchard
	Sustainability					Raj Ramesar
	Outreach & Communications					TBA
	CVD					Michele Ramsay
	HIV/AIDS					Mogomotsi Matshaba
	Rare Disease					Zane Lombard
	Discussion & IEC Feedback
	Closing by Steering Committee Chair: Nicola Mulder
	Tea available
	AD 11				AD 1
17:10-18:50	H3Africa Steering Committee & IEC (18:30 DBAC Joins)				CRF Facilitator: Katherine Johnson
19:00	Drinks Reception KCC Main Foyer
19:30	Formal Dinner MH 1 Tribute to Professor Bongani Mayosi by Professor Raj Ramesar

Joint African Society of Human Genetics and H3Africa Wednesday 19 September

7:30	Registration
9:00-11:00	Opening Session
10:00	Plenary 1 Presenter: Eric Green (USA)
10:50	Tribute to Bongani Mayosi
11:00-11:30	Tea
11:30-13:00	Session 1 – African population genetics
13:00-14:00	Lunch and Poster viewing (Promega – short trade talk)
14:00-15:30	Session 2 – Bioinformatics Training and Young researchers
15:30-16:00	Tea
16:00-17:30	Session 3 – H3Africa Consortium Showcase
17:30 – 18:45	Panel Discussion: Sustainability of Genomics and Human Genetics in Africa
19:00	Opening Reception

African Society of Human Genetics (Day Two) Thursday 20 September

8:00	Registration
8:00	Workshop: Challenges in publishing from Africa
9:00-10:30	Session 4 Part 1 – Epigenomics and Functional Genomics
10:30-11:00	Tea
11:00-12:30	Session 5 Part 2 – Epigenomics and Functional Genomics
12:30-14:00	Lunch Box and Open Forum: Establishing a ‘2020 Vision’ for Genomics
14:00-15:30	Session 6 – Host Genetics and Infectious Disease
15:30-16:00	Tea
16:00	Panel Discussion: Translational genomics
17:00	AGM
19:00	Gala Dinner

African Society of Human Genetics (Day Three) Friday 21 September

8:00	Registration
8:00	Workshop: Career opportunities for young African geneticists
9:00-9:45	Plenary 2
9:45-11:10	Session 7 – Genomics of Rare Diseases
11:10-11:40	Tea
11:40-12:55	Session 8 – Ethics and Genomics in Africa
12:55-14:00	Lunch and Poster viewing
14:00-16:00	Session 9 – Complex Disease Genomics
16:00	Strategic planning for the AfSHG: Building skills and resources for genomics, epigenetics and bioinformatics research for Africa
17:30	AfSHG Committee Meeting

H3Africa Community Engagement Workshop Thursday 20 September

	Session detail	Facilitator (s)
8.30 -9.00 (30 mins)	Welcome and intro · Introduction/ workshop objectives · Getting to know each other exercise · Review workshop expectations	Paulina Tindana/Lillian Mutengu
9.00 – 9-30 (30 minutes)	Overview · Types of engagement and related aims · H3Africa CE guidelines-Key highlights	Paulina Tindana/All
9.30-11.30 (2 hours)	· Peer review and Group discussions on projects’ CE plans and needs · Discussions	All
COFFEE/TEA BREAK 11.30-12.00 (30mins)
12.00 – 1.30 (1 hour 30 mins)	Evaluation of engagement methods · Overview of evaluation methods and questions and discussion · Group exercise	Dorcas Kamuya
LUNCH BREAK 13:30- 14:30 (1 hour)
2.30 – 4.30 (2 hours)	CE Evaluation support needs · Group work on developing/strengthening CE and Evaluation plans · Feedback	Lillian Mutengu/Victoria Nembaware
3.30-4.15 (45mins)	· CE and feedback of findings (sharing aggregate research findings	Paulina Tindana /Stuart Ali (AWIGen Experience)
4.30-5.15 (45mins)	Brainstorm on proposed workplan for H3Africa CE activities · How can consortium members support each other? · MESH platform · External support needed? · small groups discuss/plenary feedback · Next steps	All
5.15-5.30	Brief evaluation and close	Jantina de Vries
5.30 END
7:30	Dinner (Venue: TBA)

October 23, 2018

Twelfth H3Africa Consortium Meeting

Twelfth H3Africa Consortium Meeting , Venues: Kigali Convention Centre (KCC), Radisson Blu Hotel & Remera College of Medicine and Health Sciences, Kigali Rwanda

October 14, 2018