H3Africa Consortium Group Photo

La Palm Royal Beach Hotel
Accra, Ghana
May 16-18, 2013

Meeting Minutes

Agenda

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Thursday, May 16

Working Group Meetings

8:30 – 10:30 a.m.Ethics and Regulatory Issues Working Group
Chairs: Jantina De Vries, University of Cape Town, R.S.A..
.Discussion Facilitators: Ebony Bookman, NIH/NHGRI, U.S.A. and Katherine Littler, Wellcome Trust, UK
10:30 a.m. – 12:30 p.m.Biorepository Users Working Group
Chairs: Akin Abayomi, University of Stellenbosch, R.S.A. and Alan Christoffels, South African National Bioinformatics Institute, R.S.A.
Discussion Facilitator: Louise Wideroff, NIH/NEI, U.S.A.
12:30 – 1:30 p.m.Lunch
1:30 – 3:30 p.m.Data Sharing, Access, Release Working Group
Chairs: Nicola Mulder, University of Cape Town, R.S.A. and Bamidele Tayo, Loyola University, U.S.A.
Discussion Facilitators: Maria Giovanni, NIH/NIAID, U.S.A. and Audrey Duncanson, Wellcome Trust, U.K.
3:30 – 4:30 p.m.Marker Paper and Publications Working Group
Chairs: Michele Ramsay, Wits Health Consortium, R.S.A., Charles Rotimi, NIH/NHGRI, U.S.A. and Enock Matovu, Makerere University, Uganda
Discussion Facilitator: Audrey Duncanson, Wellcome Trust, U.K.
4:30 – 5:15 p.m.Phenotype Harmonization Working Group
Coordinator: Alia Benkahla, Institute Pasteur of Tunis, Tunisia
Discussion Facilitator: Jeff Struewing, NIH/NHGRI, U.S.A.
5:15 – 6:00 p.m.Genome Analysis Working Group
Chairs: Debo Adeyemo, NIH/NHGRI, U.S.A. and Zane Lombard, Wits Health Consortium, R.S.A.
Discussion Facilitator: Jeff Struewing, NIH/NHGRI, U.S.A.
6:00 – 7:00 p.m.Social Hour
7:00 p.m.Dinner
Friday May 17

Opening Remarks
Chair: Alash’le Abimiku, Institute of Human Virology, Nigeria

8:00 – 8:05 a.m.Alash’le Abimiku, Chair of H3Africa Steering Committee
8:05 – 8:15 a.m.Eric Green, Director of NIH/NHGRI, U.S.A.
8:15 – 8:25 a.m.Audrey Duncanson, Wellcome Trust, U.K.
8:25 – 8:45 a.m.Honorable Dr. Oteng-Adjei, Minister of Environment, Science, Technology & Innovation, Ghana

Wellcome Trust Grantee Research Project Presentations
Katherine Littler, Wellcome Trust, U.K.

8:45 – 9:10 a.m.Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa

Albert Amoah, University of Ghana Medical School, Ghana

9:10 – 9:35 a.m.Genetics of rheumatic heart disease and molecular epidemiology of streptococcus pyogenes pharyngitis

Gasnat Shaboodien, University of Cape Town, R.S.A.

9:10 – 9:35 a.m.TrypanoGEN: an integrated approach to the identification of genetic determinants of susceptibility to trypanosomiasis

Enock Matovu, Makerere University College of Veterinary Medicine, Uganda

NIH Research Project Program Grantee Presentations
Chair: Jane Peterson, NIH/NHGRI, U.S.A.

10:00 – 10:25 a.m.Genomic and environmental risk factors for cardiometabolic disease in Africans

Michele Ramsay, Wits Health Consortium & NHLS, R.S.A.

10:25 – 10:50 a.m./wp-content/uploads/2018/10/7_Adu_Ojo.pdfH3Africa Kidney Disease Research Network

Dwomoa Adu, University of Ghana Medical School, Ghana

Lolu Ojo, University of Michigan, U.S.A.

10:50 – 11:15 a.m.Contribution of genetic variation to pharmacokinetic variability and toxicity in patients undergoing multi-drug tuberculosis treatment in Sub-Saharan Africa

Dissou Affolabi, National Hospital for Tuberculosis and Pulmonary Diseases, Benin

11:15 – 11:40 a.m.The Genomics of Schizophrenia in the South African Xhosa People
Adam Zac Baldinger, University of Cape Town, R.S.A.
Rajkumar Ramesar, University of Cape Town, R.S.A.

NIH Biorepository Pilot Project Program Grantee Presentations
Chair: Louise Wideroff, NIH/NEI, U.S.A.

11:40 a.m. – 12:05 p.m.IHVN H3Africa Biorepository (I-HAB) Initiative

Alash’le G. Abimiku, Institute of Human Virology, Nigeria

12:05 – 12:30 p.m.Development of H3 Africa Biorepositories to facilitate studies on Biodiversity, Disease & Pharmacogenomics of African Populations

Akin Abayomi, University of Stellenbosch & NHLS, R.S.A.

12:30 – 1:30 p.m.Lunch and official photograph

NIH Bioinformatics Network Program (H3ABioNet) Grantee Presentation
Chair: Jane Peterson, NIH/NHGRI, U.S.A.

1:30 – 2:30 p.m.H3BioNet

Nicola Mulder, University of Cape Town, R.S.A.

H3ABionet Bulletin – May 2013

Working Group Recommendations

2:30 – 4:00 p.m.Data Sharing, Access, Release Working Group

Chair: Nicola Mulder, University of Cape Town, R.S.A. and Bamidele Tayo, Loyola University, U.S.A.

Discussion Facilitators: Rex Chisholm, Northwestern University, U.S.A. and Oduola Ayoade, University of Ibadan, Nigeria

Data Sharing Working Group Handout

4:00 – 5:30 p.m.Ethics and Regulatory Issues Working Group

Chair: Charmaine Royal, Duke Institute for Genome Sciences and Policy, U.S.A. Ruth Chadwick, Cardiff University, U.K.

6:00 – 7:00 p.m.Social Hour
7:00 p.m.Dinner
After-dinner speakers:Overcoming Infrastructural Challenges to Big Science in Africa David Ofori-Adjei, Ghana College of Physicians and Surgeons Population-based Systems Genomics Approaches for Studying Malaria and Sickle Cell Disease Philip Awadalla, Sainte Justine Hospital, Canada
Saturday, May 18

Committee Meeting

7:30 – 9:00 a.m.Private Independent Expert Committee Breakfast
Chairs: Kay Davies, University of Oxford, U.K. and Barry Bloom, Harvard School of Public Health, U.S.A.

Working Group Recommendations Continued

9:15 – 10:45 a.m.Biorepository Users Working Group Recommendations

Discussion Facilitators: Robert Hewitt, SFR/ESBB, France and Chana Rabiner, NIH/NCI, U.S.A.

Introductions from Working Group Chairs

Akin Abayomi, University of Stellenbosch & NHLS, R.S.A. and Alan Christoffels, South African National Bioinformatics Institute, R.S.A.

Biobanking Survey & Biospecimin Deposit

Tay Croxton, Beverly van Rooyen and Carmen Swanepoel

MTA & Biospecimin Release

Christine Beiswanger, Emilomo Ogbe and Beverley van Rooyen

H3Africa Consortium and H3ABioNet Standardization

Alan Christoffels and Judit Kumuthini

10:45 – 11:45 a.m.Marker Paper and Publications Working Group

Chairs: Michele Ramsay, Wits Health Consortium, R.S.A., Charles Rotimi, NIH/NHGRI, U.S.A. and Enock Matovu, Makerere University, Uganda

Discussion Facilitator: Kay Davies, University of Oxford, U.K.

11:45 a.m. – 12:00 p.m.Break
12:00 – 1:00 p.m.Phenotype Harmonization Working Group

Chair: Alia Benkahla, Institute Pasteur of Tunis, Tunisia

Discussion Facilitator: Barry Bloom, Harvard School of Public Health, U.S.A

1:00 – 2:00 p.m.Genome Analysis Working Group Recommendations

Chair: Debo Adeyemo, NIH/NHGRI, U.S.A. and Zane Lombard, Wits Health Consortium, R.S.A.

Discussion Facilitator: Philip Awadalla, Sainte Justine Hospital, Canada

2:00 – 3:30 p.m.Lunch and Steering Committee Meeting

Closing Session
Chair: Alash’le Abimiku, Institute of Human Virology, Nigeria

3:30 – 4:00 p.m.Report back from the Independent Expert Committee

Discussion Facilitators: Kay Davies, University of Oxford, U.K. and Barry Bloom, Harvard School of Public Health, U.S.A.

4:00 – 4:30 p.m.Report back from the Steering Committee

Chair: Alash’le Abimiku

4:30 – 5:00 p.m.Identification of meeting action items

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