We welcome you to the Sixteenth Meeting of the H3Africa Consortium. As you know we were due to meet in Tanzania this September with the African Society of Human Genetics. Unfortunately we have all been forced into detours which has created opportunities for creative engagement.  We hope that our virtual meeting experience will offer as many opportunities to share research findings and build upon them. We will dedicate time to explore research areas beyond the current scope of H3Africa to foster broader sustainable networks. Our early career scientists are always a key feature of H3Africa meetings, there will be several opportunities to engage young scientists during presentation and poster sessions. Our Principal Investigators and Scientists have also responded to the Covid-19 pandemic at various levels and are keen to share their experiences and findings with you. We appreciate your participation during this virtual meeting and look forward to meeting you in-person in time.

Monday, Sep 7, 2020

Speaker NamePresentation TitleAction
Mogomotsi MatshabaH3Africa OverviewDownload
Solomon Ofori-AcquahSickleGenAfrica: Defining Risk Factors of
Organ Dysfunctions in Sickle Sell Disease
Mahmoud SaniSickleGenAfrica Project 3: Echo-
Cardiovascular Phenotypes in Sickle
Cell Disease
Emma WeinerEstablishing a Baseline for Developmental Disorder
Diagnosis by evaluating current diagnostic
processes and mapping common benign copy
number variation in Africa
Nadia CarstensDeciphering Developmental
Disorders in Africa
Adeyinka AshayeEyes of Africa: The genetics
of blindness: Progress report
Jantina de VriesStigma in African genomics - when it is a risk and when it may not be Download

Tuesday, Sep 8, 2020

Speaker NamePresentation TitleAction
Alash'le AbimikuInstitute of Human Virology Nigeria H3Africa Biorepository (I AB) UpdateDownload
Elizabeth MayneCOVID-19 CLSDownload
Caleb KibitResidential Training Going Virtual: Challenges and opportunitiesDownload
Dan MasigaThree Years On: Updates, Successes and
Kaitlyn FlynnEvaluating whole exome sequencing on the Thermo Fisher Ion Torrent S5™ as a potential tool for diagnosing developmental disordersPresentation OR Recording
Ibrahim GuindoClinical and genetic aspects of amyotrophic lateral sclerosis in MaliPresentation OR Recording
Henrick AdudaCharacterizing transmission dynamics of recent viral hemorrhagic fever outbreaks in UgandaPresentation OR Recording
Tafadzwa MachipisaPreliminary tissue enrichment findings
from DEPICT analysis in RHDGen
Alaine MarsdenImmunoglobulin Heavy Chain Genetic Diversity with Large
Structural Variation in an African Population
Joseph AtemiaMining next generation sequencing data for genetic diversity assessment of eastern Africa finger millet blast fungusPresentation OR Recording
Lakshmi SujeenThe use of supervised machine learning algorithms to study and predict physico chemical
characteristics and biological behavior of nanofibrous scaffolds for skin tissue engineering
Presentation OR Recording
Abdoulaye YalcouyeGenetic aspects of hereditary hearing impairment in MaliPresentation OR Recording
Diabate OudouIn silico analysis of Pfdhfr gene mutations and their effects on the protein functionPresentation OR Recording
Magambo PhillipTrypanoGEN+; From GWAS to candidate genesDownload
Enock MatovuUpdates from TrypanoGEN +Download
Olufemi AromolaranEssential gene prediction in Drosophila melanogaster using machine
learning approaches based on sequence
and functional features

Wednesday, Sep 9, 2020

Speaker NamePresentation TitleAction
Segun FatumoIntergenerational
Epigenomics of PTSD and Trauma in
Rwanda: Update and Scientific accomplishments
Erisa SabakakiEthical and social issues in
informed consent processes in
African genomic research

Thursday, Sep 10, 2020

Speaker NamePresentation TitleAction
Florence KivunikeBRecA : Three Years of Nurturing Bioinformatics and
Genomics in Uganda
Collins Morang'aRegulation of cGAS
STING Mediated DNA Sensing Pathway by Oligoadenylate Synthetase like Protein during Plasmodium falciparum Infections
Olu AjibolaDiversity of putative
Plasmodium falciparum vaccine candidates across different malaria
endemic settings in Africa
Dominic AmuzuHigh throughput PCR RFLP assay for identification of glycophorin B deletion variantsDownload
Cheickna CisseIdentification and 3D model prediction of the multistage antimalarial target
Plasmepsin X from Plasmodium falciparum (PfPImx)

H3Africa Projects and Guests

Augemented Posters

click/tab on the name or picture for bio

Alash’le G Abimiku

Alash’le Abimiku has been pivotal to the establishment of a long-term collaborations between Institute of Human Virology Nigeria (IHVN) and other Institutions in Nigeria and investigators at the Institute of Human Virology University of Maryland School of Medicine, Baltimore where she is an Associate Professor

Solomon Ofori-Acquah

Ofori-Acquah was appointed Dean of the School of Biomedical and Allied Health Sciences in the University of Ghana in January 2017, and as Associate Professor of Medicine and Human Genetics, and Director of the Center for Translational and International Hematology in the University of Pittsburgh in 2013.

Ashaye Adeyenka

Adeyinka Ashaye is the Head of the Department of Ophthalmology, College of Medicine, University of Ibadan, Ibadan, Nigeria. She is the Principal Investigator for Eyes of Africa: The genetics of Blindness study funded by NIH and Welcome Trust.

Dominic Amuzu

I am a student pursuing a PhD in Biochemistry (Human Genetics) at the Department of Biochemistry, Cell and Molecular Biology, University of Ghana. As a PhD research fellow, I am investigating the effect of glycophorin B gene deletions on Plasmodium falciparum invasion of erythrocytes and growth.

Amayoa Francis Anyaka

Amayoa Francis Anyaka is the Environment Officer of Uganda Prison Service. He is also a final year student of Master of Health Sciences in Bioethics at the School of Biomedical Sciences, Makerere University.

Kidist Bobosha

I am a Senior Researcher at the Armauer Hansen Research Institute (AHRI) and serve as head of the Mycobacterial Diseases Research Directorate. I have been working for the AHRI since 2003.

Nadia Carstens

Dr Carstens is a medical scientist specializing in the field of human genetics. She joined the Division of Human Genetics (National Health Laboratory Service and University of the Witwatersrand) as a principal medical scientist in 2016.

Cheickna Cisse

Cheickna CISSE, PhD is an assistant professor of Biochemistry and Bioinformatics at the the University of Sciences, Techniques and Technologies of Bamako (USTTB) since 2016. In addition to his training commitments, CISSE is leading research activities on structural Bioinformatics into the African Center of Excellence in Bioinformatics of Bamako (ACE-B).

Francis Collins

Francis S. Collins, M.D., Ph.D. was appointed the 16th Director of the National Institutes of Health (NIH) by President Barack Obama and confirmed by the Senate. He was sworn in on August 17, 2009.

Jeremy Farrar

Director of the Oxford University Clinical Research Unit in Vietnam for 18 years. His research interests were infectious diseases, tropical health and emerging infections. He has published over 500 peer-reviewed scientific papers, mentored many dozens of students and fellows, and served as Chair on several advisory boards for governments and global organisations, including the World Health Organization.

Segun Fatumo

Assistant Professor of Genetic Epidemiology and Bioinformatics at the MRC/UVRI Uganda and London School of Hygiene and Tropical Medicine (LSHTM)

Kaitlyn Flynn

Current MSc (Med) student at the University of the Witwatersrand. Working on evaluating whole exome sequencing as a possible diagnostic tool for developmental disorders in South Africa. Completed my undergraduate degree at the University of Pretoria followed by my BHSc Honours (Human Genetics) degree at the University of the Witwatersrand. Passionate scientist looking to expand my knowledge

Christian Happi

Sep 8 @ 12:55pm GMT

Professor of Molecular Biology and Genomics; Director, African Centre of Excellence for Genomics of Infectious Diseases

Moses Joloba

Moses Joloba is the current Dean School of Biomedical Sciences, Makerere University College of Health Sciences. He was Head of Department of Medical Microbiology (2005 – 2014). Professor Moses Joloba has developed skills in conducting clinical microbiology and molecular biology, laboratory-based research and training as well as building laboratory capacity in Uganda and other countries.

Florence Nameere Kivunike

Florence Nameere Kivunike, is a Key Personnel and Programme Coordinator of the NIH, H3Africa bioinformatics nurturing program (BRECA) in Uganda (PIs: Dr. David Kateete, Dr. Daudi Jjingo). She is a lecturer at the School of Computing and Informatics Technologies, College of Computer and Information Sciences (COCIS), Makerere University.

Zane Lombard

Deciphering Developmental Disorders in Africa (DDD-Africa) – Evaluating Clinical Exome Sequencing in an African Setting

Tafadzwa Machipisa

Tafadzwa Machipisa is a PhD candidate at the University of Cape Town, South Africa. She is currently a visiting student at the Population Health Research Unit (PHRI) at McMaster University, Canada. Tafadzwa joined the Mayosi research group in 2015 and initially, worked on her master’s project looking at cardiomyopathies in Afrikaner families, whilst also doing the wet lab part of RHDGen. Tafadzwa’s PhD project work entails deciphering the genetics of rheumatic heart disease;

Julie Makani

Prof. Julie Makani is from the Department of Haematology and Blood Transfusion at Muhimbili University of Health and Allied Sciences (MUHAS), where Tanzania established one of the world’s largest single-center study cohorts for sickle cell disease.

Dan Masiga

Dan Masiga’s research focus is on tropical infectious diseases, which began with African trypanosomes, the subject of his doctoral studies, but extended to malaria and NTDs.

Enock Matovu

Enock Matovu obtained his PhD in Molecular Parasitology from the University of Bern, Switzerland in 2001, while he worked as a Research Officer at the Livestock Health Research Institute, Tororo, Uganda. Since then has continued his work on drug resistance and later diagnostics for African Trypanosomiasis.

Mogomotsi Matshaba

Mogomotsi Matshaba, Principal Investigator for Collaborative African Genomics Network (CAfGEN) Group is Assistant Clinical Professor of Pediatrics, Retrovirology, Baylor College of Medicine, and Executive Director- Botswana-Baylor Children’s Clinical Centre of Excellence. He is a medical graduate of University College of Dublin, Ireland.

Elizabeth Mayne

Elizabeth Mayne is a specialist haematologist and pathologist with a special interest in immunology and HIV-associated malignancy. She currently runs the leukaemia and lymphoma immunophenotyping and immunohaematology services at the National Health Laboratory Service

Ayton Meintjes

Ayton Meintjes is a Bioinformatics software engineer at CBIO. He completed a BSc in Computer Science at the University of Pretoria, and after a period of development in the commercial field, returned to do a BSc (Hons) with specialisation in Bioinformatics. In 2008, he joined the CBIO Group at UCT and has collaborated on projects mostly focusing on human population

Collins Misita Morang'a

Collins Misita Morang’a is a PhD research fellow at WACCBIP, funded by the Wellcome Trust DELTAS Programme at the University of Ghana. He finished his studies in Biochemistry from Egerton University and obtained his Master of Science Degree in Molecular Biology from Maseno University in Kenya.

Lynn Morris

Lynn Morris is the Interim Executive Director of the National Institute for Communicable Diseases (NICD) and Principal Medical Scientist in the HIV Virology Section, Centre for HIV & STI’s at the NICD. She holds a joint appointment as Research Professor at the University of the Witwatersrand and is an Honorary Senior Scientist at CAPRISA.

Nicola Mulder

Professor Nicky Mulder heads the Computational Biology Division at the University of Cape Town, and leads H3ABioNet, a large Pan African Bioinformatics Network of 27 institutions in 17 countries. H3ABioNet aims to develop bioinformatics capacity to enable genomic data analysis on the continent. She is also co-PI of a Sickle Cell Data Coordinating Centre.

Leon Mutesa

Leon Mutesa, MD, PhD Professor of Human Genetics Director of Center for Human Genetics College of Medicine and Health Sciences University of Rwanda Dr. Mutesa is professor of human genetics at the college of medicine and health sciences-University of Rwanda. He obtained his MD from the university of Rwanda in 2003 and his PhD in 2009 from the university of Liege-Belgium where he also completed his post-doc in 2011.

Alfred Amambua Ngwa

Studied Biochemistry and molecular parasitology at the Unversity of Buea, earning a PhD in 2004. Spent 5 years at MRC Unit Gambia at the London School of hygeiene and Tropical medicine, researching in Plasmodium falciparum invasion pathways and genetic diversity. Has been an MRCG at LSTMH career development

John Nkengasong

Dr John Nkengasong was appointed first Director of Africa CDC in November 2016 to provide strategic direction and position it as an African-owned institution supporting countries to improve surveillance, preparedness, response and prevention of disease threats.

Dimpho Ralefala

Dimpho Ralefala is a PhD fellow specialising in Bioethics under the Individual Findings in Genetics Research in Africa (IFGENERA) H3Africa ELSI Collaborative Centre at the University of Cape Town. She holds a Masters of Social Science degree in Health Research Ethics (2017) from the University of KwaZulu Natal in South Africa

Michèle Ramsay

Michèle Ramsay, Ph.D., is a professor in the Division of Human Genetics at the National Health Laboratory Service and University of the Witwatersrand (Wits) in Johannesburg. Her research interests include the genetic basis and molecular epidemiology of single gene disorders in South African populations and the role of genetic and epigenetic variation in the molecular aetiology

Simone Richardson

Simone is currently a postdoctoral fellow in the Antibody Immunity Research Unit of the National Institute for Communicable Diseases (NICD) and at the University of the Witwatersrand, South Africa, where she also completed her PhD.

Erisa Mwaka Sabakaki

Dr. Erisa Mwaka is an orthopaedic surgeon, academician and bioethicist. He holds a Bachelors of Medicine and Bachelors of Surgery (Makerere University, Uganda), Master of Medicine (Makerere University, Uganda), Master of Social Sciences in Health Research Ethics (University of Kwazulu Natal, South Africa) and PhD (Fukui University, Japan).

Mahmoud Umar Sani

Cardiologist with the Department of Medicine, Bayero University Kano (BUK)/Aminu Kano Teaching Hospital (AKTH), Kano, Nigeria. He received his medical degree in 1993 from the Ahmadu Bello University Zaria, Nigeria and completed residency in Internal Medicine and Cardiology in 2002.

Jantina de Vries

Cardiologist with the Department of Medicine, Bayero University Kano (BUK)/Aminu Kano Teaching Hospital (AKTH), Kano, Nigeria. He received his medical degree in 1993 from the Ahmadu Bello University Zaria, Nigeria and completed residency in Internal Medicine and Cardiology in 2002.

Emma Wiener

Emma completed a BSc in Genetics and Biochemistry in 2011 and Biochemistry honours in 2012 at the University of Kwa-Zulu Natal. She then went on to do the Graduate Entry Medical Program MBBCH at University of Witwatersrand graduating 2016 after which she decided to pursue research and do a PhD in Human genetics

click/tab on the name or picture for bio

Gavin Churchyard

Gavin Churchyard is a specialist physician, internationally renowned for his contributions in tuberculosis (TB). He is the founder and CEO of The Aurum Institute NPC, an independent, public benefit organisation that focuses on TB and HIV service delivery, management and research. He is an Honorary Professor at the University of Witwatersrand,

Mark Daly

Mark Daly is an institute member of the Broad Institute and co-director of the Program in Medical and Population Genetics. His research primarily focuses on the development and application of statistical methods for the discovery and interpretation of

Melissa Gymrek

I am currently an assistant professor at the University of California San Diego in the Departments of Medicine and Computer Science & Engineering.I received my PhD in Bioinformatics and Integrative Genomics from the Harvard/MIT Division of Health Sciences and Technology under the supervision of Yaniv Erlich and Mark Daly

Heidi Rehm

Heidi Rehm is a clinical genomicist and past Director of the Laboratory for Molecular Medicine at the Partners Personalized Medicine. She is now the Chief Genomics Officer at Massachusetts General Hospital (MGH) as well as Professor of Pathology at Harvard Medical School.

Guillaume Lettre

Guillaume Lettre is an Associate professor of Medicine at the Montreal Heart Institute and the Université de Montréal since January 2009

Angela Page

Angela Page is the Communications Manager for the Global Alliance for Genomics and Health, based at the Broad Institute of MIT and Harvard

Elissa Prichep

Elissa Prichep is Lead, Shaping the Future of Health and Healthcare, at the World Economic Forum, and based in San Francisco. Her work focuses developing and testing policies to advance precision medicine approaches in emerging economies, for which she recently released a whitepaper on Genomic Data Policy Frameworks and Ethical Tensions. She also manages the Forum’s Global Future Council on Biotechnology and is developing initiatives on health system responses to the COVID-19 pandemic.

Thomas Kariuki

Thomas Kariuki is the Director of Programmes at The African Academy of Sciences where he leads the Alliance for Accelerating Excellence in Science in Africa. He holds an honorary Professorship at the Liverpool School of Tropical Medicine and a Ph.D. in immunology from the University of York.