Tenth H3Africa Consortium Meeting

VENUE: Gaborone, Botswana

Meeting Overview

Friday, 12 May 2017
Grant Applications/Pharmacogenomics/Genome Analysis Publications & Writing Sub group/Study Coordinators
Saturday, 13 May 2017
Working Group day/Poster Sessions
Sunday, 14 May 2017
Principal Investigators/Fellow Presentation Day
Monday, 15 May 2017
Principal Investigators/Fellow Presentation Day/Sustainability Stakeholders/Poster Session


Friday, 12 May 2017 Grand Palm, Gaborone

Satellite Sessions

7:30 Registration Opens


Tshodilo B4

Serondela 1 & 2

Serondela 3 & 4

9:00-10:00 Grant Applications: Useful Tips (Informal Discussion)

Jennifer Troyer, Laura Povlich & NIH Team

Study Coordinators
10:00-11:00 GAPW Sub group
11:00-12:00 Health information resources for researchers, clinicians and consumers

Dineo Ketshogileng


Lunch (See Exhibitors in Foyer)

13:00-13:15 Chair: Michèle Ramsay Study Coordinators GAPW Sub group (if required)
Welcome: Importance of pharmacogenomics in an African setting

Michèle Ramsay

13:15-13:30 GSK and the OpenLab: Characterization of ADME gene variation in populations by exome sequencing

Presenter: Matt Hall (GSK)

13:30-13:40 Status of the H3A population genetics study and potential overlap with the pharmacogenomics project

Presenter: Debo Adeyemo

13:40-14:00 Proposed workplan for the project                                               Presenter: Scott Hazelhurst
14:00-14:20 Small group discussions iScan Genotyping Platform at CPGR (Scientific, Technical & Logitical Engagement)-

Presenters: Judith Hornby & Lindsay Petersen (CPGR)

14:20-14:50 Report back and discussions
14:50-15:00 Discussion (Led by Scott Hazelhurst)
15:00 Tea/Coffee Available
15:00-17:00 Optional Excursion: Three Chiefs Monument; Botswana-Baylor Children’s Clinical Centre of Excellence; University of Botswana and Innovation Hub
17:30-19:00 Health information resources for researchers, clinicians, and consumers by Dineo Ketshogileng (if required) Pre Dinner Meeting: H3Africa Principal Investigators Pre Dinner Meeting: IEC & Funders

Saturday, 13 May 2017 Saturday Grandpalm Gaborone

Working Group Day

7:30 Registration Opens
Venues Serondela 1&2 Tshodilo B4 Tshodilo A Serondela 3 Serondela 4
8:30-9:30 Genome Analysis & GAPW Subgroup Chairs: Debo Adeyemo & Zane Lombard; Neil Hanchard


Jennifer Troyer & Audrey Duncanson

Biorepository PI WG Chairing: Alash’le Abimiku Rapporteur: Laura Skow Ethics & Study Coordinators Chair:  Aminu Yakubu Rapporteur: Karen Lacourciere Sustainability WG Chair: Raj Ramesar Rapporteur: Mark Guyer
9:30-10:30 Study Coordinators Chairs: Veronica Francis & Slee Mhbele Rapporteur: Robin Mason Phenotype Harmonization Chair: Alia Benkahla Rapporteur: Jeff Streuwing
10:30-11:25 Tea break/Poster session
11:30–12:30 DBAC Chair: Nicky Mulder


Audrey Duncanson & Jennifer Troyer

Joint Ethics & Regulatory Issues  & CEWG  Chair: Aminu Yakubu Rapporteur: Katherine Littler HIV/AIDS Chair: Mogomotsi Matshaba & Xavier Gomez-Olive  Rapporteur: Bonnie Joubert ECTWG Chairs: Raj Ramesar & Samar Kassim Rapporteur: Laura Povlich
12:30– 13:30 CVD Chair: Akinlolu Ojo Rapporteur: Marva Moxey-Mims
13:30-14:25 Lunch/Poster Session
Working Group Report Back Session Venue: Tshodilo A
14:30-15:40 Chairs: Ayoade Oduola & Graeme Mardon Presenter
Genome Analysis & GAPW Adebowale Adeyemo/Neil Hanchard
Phenotype Harmonization Jeff Struewing
Biorepository PI  (15 min) Alash’le Abimiku
DBAC Nicola Mulder
Sustainability Raj Ramesar/Dwomoa Adu
15:40-16:45 Chairs: Solomon Nwaka & Sununguko Wata Mpoloka
Community Engagement Paul Ndebele
Education & Coordinated Training Raj Ramesar/ Samar Kassim
Ethics & Regulatory Issues WG Aminu Yakubu
Study Coordinators Veronica Francis/Slee Mbhele
HIV/AIDS Mogomotsi Matshaba/Xavier Gomez-Olive
CVD Akinlolu Ojo
Discussion & IEC Feedback
16:45-17:00 Tea break/Poster session
17:00-17:25 Title: Unlocking domestic resources for research and innovation – lessons from SANBio partnerships

Presenter: Dr Ereck Chakauya

17:30-18:30 H3Africa Steering Committee Meeting with Funders (Serondela 1-4)
18:30-19:00 Social Hour
19:30 Opening Address: Honourable Minister Dr Alfred Madigele  Ministry of Tertiary Education, Research, Science and Technology

Formal Dinner (Tshodilo C)

Sunday, 14 May 2017 Grandpalm Gaborone Tshodilo A

Principal Investigators/Fellow Presentation Day

08:00-08:05 Welcome & Introductions: Gabriel Anabwani
08:05-08:10 H3Africa Steering Committee Chair: Enock Matovu
08:10-08:50 Director, National Human Genome Research Institute, NIH:  Dr Eric Green

Presentation: Genomics, Precision Medicine, and H3Africa: Journeys to Advance Human Health

Presentation: 35 minutes Q&A: 5 minutes

Session I Chair: Barry Bloom
08:50-09:20 Project: Genomic and Environmental Risk Factors for Cardiometabolic Disease in Africans (AWI-Gen)

Title: The AWI-Gen journey: Burden of cardiometabolic diseases across six African populations

Presenter:   Michele Ramsay    Presentation: 18 minutes Q&A: 2 minutes

Title:  Factors influencing lipid levels in rural Ghanaian adults

Presenter: Godfred Agongo   Presentation: 8 minutes Q&A: 2 minutes

09:20-09:50 Project: Stroke Investigative Research & Educational Network (SIREN) Phenotypic characteristics and outcomes of stroke among Africans: Evidence from the SIREN study.

Presenter: Fred Stephen Sarfo   Presentation: 18 minutes Q&A: 2 minutes

Title: Household air pollution as a risk factor for stroke in Africans                                                                                                                                                               Presenter: Adekunle Gregory Fakunle   Presentation: 8 minutes Q&A: 2 minutes

09:50-10:10 Project: Burden, Spectrum and Aetiology of Type 2 Diabetes in sub-Saharan Africa

Title: H3A Diabetes Study: preliminary data

Presenter: Kenneth Ekoru   Presentation: 18 minutes Q&A: 2 minutes

10:10-10:30 Project: H3Africa Kidney Disease Research Network

Title: H3Africa Kidney Disease Research Network

Presenter: Dwomoa Adu   Presentation: 18 minutes Q&A: 2 minutes

10:30-11:00 Tea/Coffee
Session II Chair: Kay Davies
11:00-11:30 Project:  RHDGen: The Genetics of Rheumatic Heart Disease Network

Title:  The RHDGen Network Presenter: Bongani Mayosi   Presentation: 18 minutes Q&A: 2 minutes

Title: Genetics of RHD: An Update

Presenter: Babu Muhamed   Presentation: 8 minutes Q&A: 2 minutes

11:30-12:00 Project: Clinical and Genetic Studies of Hereditary Neurological Disorders in Mali

Title:  Neurogenetic diseases in Mali: update

Presenter: Guida Landoure

Title 1: Is Ataxia the most prevalent hereditary neurological disorder in Mali?
Title 2:  Charcot-Marie-Tooth disease study in Mali shows a genetic diversity and expands its global epidemiology

Presenter 1 & 2: Abdoulaye Tamega &  Abdoulaye Yalcouye   Presentation: 8 minutes Q&A: 2 minutes (each)

12:00-12:20 Project: The Nasopharyngeal Microbiome and Respiratory Disease in African Children

Title: The nasopharyngeal microbiome as a biomarker for pneumonia in African children

Presenter:  Shantelle Claassen-Weitz   Presentation: 18 minutes Q&A: 2 minutes

12:20-12:50 Project: The Genomics of Schizophrenia in the South African Xhosa People Presenter: Raj Ramesar    Presentation: 18 minutes Q&A: 2 minutes

Presenter: Lerato Majara   Presentation: 8 minutes Q&A: 2 minutes

12:50-13:50 Lunch
Session III Chair: Rex Chisholm
14:00-14:20 Project: Establishment of an H3Africa Biorepository at Clinical Laboratory Services

Presenter: Elizabeth Mayne   Presentation: 18 minutes Q&A: 2 minutes

14:20-14:50 Project:   IHVN H3Africa Biorepository (I-HAB) Initiative

Title: Update from H3Africa W/Africa regional biorepository

Presenter: Alash’le Abimiku   Presentation: 18 minutes Q&A: 2 minutes

Title: TBA

Presenter: James Onyemata   Presentation: 8 minutes Q&A: 2 minutes

14:50-15:10 Project:  Integrated Biorepository of H3Africa Uganda – IBRH3AU

Presenter: TBA    Presentation: 18 minutes Q&A: 2 minutes

15:10-15:30 H3Africa Data Archive/EGA Data Submission

Presenter: Sumir Panji   Presentation: 18 minutes Q&A: 2 minutes

Gather at the Departure Point in the Hotel Parking Area
16:00 Depart for the Mokolodi Bush Braai
Game Drive (Optional)/Social Hour
18:00 Mokolodi Bush Braai
Return to Hotel