Twelfth H3Africa Consortium Meeting
VENUE: Kigali Convention Centre (KCC), Radisson Blu Hotel & Remera College of Medicine and Health Sciences Kigali Rwanda
| Sunday 16 September |
| H3Africa Fellows Day/Environmental Health in Africa Workshop/Poster Sessions |
| Monday 17 September |
| H3Africa Principal Investigators /Working Group Sessions/Genomic Medicine & Translational Research/Poster Sessions |
| Tuesday 18 September |
| H3Africa Principal Investigators/ Sustainability Panel Discussion/Working Group Sessions/Poster Sessions |
| Wednesday 19 September |
| Joint African Society of Human Genetics and H3Africa |
| Thursday 20 September |
| African Society of Human Genetics |
| Friday 21 September |
| African Society of Human Genetics |
| Saturday 22 September |
| Next Generation Sequencing Workshop
Analysis for Monogenic Disease in Africa Populations |
| Sunday 23 September |
| Next Generation Sequencing Workshop
Analysis for Monogenic Disease in Africa Populations |
Gallery
| 7:30 | Bus leaves Radisson Blu Hotel | |
| 8:00 – 8:30 | Registration | |
| 8:30 – 9:10 | Welcoming address by Prof Leon Mutesa, Associate Professor of Human Genetics, Director of Center for Human Genetics, College of Medicine and Health Sciences, University of Rwanda | |
| SESSION 1: Eukaryotes
Chair— |
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| 09:10 – 10:00 | KEYNOTE speaker: | |
| 10:00 – 10:10 | Ahouty Bernardin | HLA-G 14-bp Ins associated with decreased risk of the human sleeping sickness within Côte d’Ivoire population |
| 10:10 – 10:20 | Windingoudi Justin Kabore | Beyond GWAS: eQTL to assign function to SNP |
| 10:20 – 10:30 | Kolapo Oyebola | Assessing human genetic polymorphisms and varying efficacy of artemisinin-based combination treatment of malaria in Nigeria |
| 10:30 – 10:40 | Diane Mutumwinka | PiggyBac-based screening identified BEM4 as a suppressor to rescue growth defects in och1-disrupted yeast cells |
| 10:40 – 10:50 | Yasmine Ochi | Characterization of Inter-species Protein Interactions: Use of SLiM motifs to infer interactions between
Plasmodium falciparum and its hosts |
| 10:50 – 11:00 | Questions and discussion | |
| 11:00 – 11:30 | MORNING TEA/COFFEE BREAK and POSTER SESSION | |
| SESSION 2: Bacteria and viruses
Chair— |
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| 11:30 – 12:20 | KEYNOTE: Prof Babatunde Salako, Director-General/CEO, Nigerian Institute of Medical Research (NIMR) | |
| 12:20 – 12:30 | Benard Kulohoma | Peripheral blood RNA gene expression in children with pneumococcal meningitis: a prospective case control study. |
| 12:30 – 12:40 | Busisiwe Mlotshwa | Characterization of active TB disease establishment in HIV/ TB co-infected children in sub-Saharan Africa using integrated genomic analyses |
| 12:40 – 12:50 | Erdaw Tachbele | Prevalence of Virological Failure and Acquired Drug Resistance Mutations detected by Deep Sequencing in virologic failures among Antiretroviral Treatment Experienced HIV-1 patients in South Omo, Ethiopia. |
| 12:30 – 12:45 | Felix Sizwe Dube | Characterisation of lineage and locus-specific variations associated with of pneumococcal carriage dynamics post PCV-13 implementation in an African birth cohort: The Drakenstein Child Health Study |
| 12:45– 12:55 | Edgar Kigozi | Practicability of Next Generation Sequencing in a Low income African Setting with A focus on Whole Genome Sequencing of Multi-drug Resistant M. tuberculosis isolates from Uganda |
| 12:55 – 13:05 | Marion Amujal | Nonsynonymous genetic variants in chemokines and their cognate ligands important in HIV/AIDS disease progression in a Ugandan paediatric population attending Baylor College of Medicine children’s Foundation Clinical Centers of Excellence. |
| 13:05 – 13:15 | San James | MicroGWAS: A fast, reliable and user-friendly web-based tool for Genome-wide analyses of microbe data |
| 13:15 – 13:30 | Questions and Discussion | |
| 13:30 – 14:15 | LUNCH and POSTER SESSION | |
| SESSION 3: Non-Infectious Diseases
Chair— |
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| 14:15 – 14:25 | Segun Fatumo | Analysis of multiple related phenotypes in a sub-Saharan Africa population genome-wide association study |
| 14:25 – 14:35 | Edmond Wonkam | Identifying new genes and variants involved in Hearing Impairment (HI) in Cameroon, using Next Generation Sequence (NGS) data |
| 14:35 – 14:45 | Ernestine Kubi | Sickle Cell Trait and Chronic Kidney Disease |
| 14:45 – 14:55 | Gerrye Mubungu Lumbono | Frequency of minor anomalies in Congolese newborn |
| 14:55 – 15:05 | Lord Gowans | Missense Mutations in KIF4A Alter Dental Morphogenesis Resulting in X-linked Taurodontism, Microdontia and Dens-Invaginatus |
| 15:05 – 15:15 | Oladimeji Adebayo | Genomic and environmental determinants of LVH among West Africans with stroke. Insight from Stroke Investigative Research and Education Network (SIREN) study |
| 15:15 – 15:25 | Gerald Mboowa | Charting the Genetic Architecture of Clinically Relevant Variations from the Collaborative African Genomics Network (CAfGEN) Exomes Using ClinVar Database |
| 15:25 – 15:35 | Paul Katongole | Role of gut microbiota in the pathogenesis of Prostate cancer in Sub-Saharan Africa |
| 15:35 – 15:50 | Questions and Discussion | |
| 15:50 – 16:15 | Afternoon TEA/Coffee Break | |
| Closing, announcement of awards and vote of thanks:
Chair— |
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| 16:15 – 16:25 | Vote of thanks | |
| 16:25 – 16:45 | Announcement of H3Africa Fellows’ Day Presentation Prize Winners | |
| 16:45 – 17:00 | Bus leaves to Radisson Blu Hotel | |
| 18:30 | PIZZA DINNER at Filini KCC | |
| Time | Theme | Activities and Speakers |
| 7:00 | Registration | AD 12 Foyer |
| 8:00 – 8:15 | Welcome: Gwen Collman, Director of NIEHS Division of Extramural Research and Training
Charge of the workshop: Kim McAllister and Bonnie Joubert, NIEHS |
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| 8:15 – 8:30 | History and Directions of the H3Africa Consortium
Michelle Skelton, University of Cape Town |
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| 8:30 – 9:00 | Global Environmental and Occupational (GEO) Health | The Michigan-West Africa GEOHealth Hub: Environmental Exposures due to Informal
E-waste Recycling Activities and the Health of Workers Julius Fobil, University of Ghana Exposure focus: electronic waste |
| 9:00 – 9:30 | East Africa GEOHealth Hub (Ethiopia): Ambient Air Pollution Exposure and Child Respiratory Health in Ethiopia, Uganda, Rwanda, and Kenya
Abera Kumie, Addis Ababa University Exposure focus: ambient air pollution |
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| 9:30 – 9:45 | Break | |
| 9:45 – 10:15 | Biomarkers and Mechanisms | Mycotoxin Biomarkers and Children’s Health in Africa: Translation of Basic Research to Public Health Prevention
Joshua Smith, Johns Hopkins University Exposure focus: mold |
| 10:15 – 10:45 | Heavy Metal Exposure and Cardiometabolic Phenotypes
Cathrine Hoyo, North Carolina State University Exposure focus: metals |
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| 10:45 – 11:15 | Toxicodietary and Genetic Determinants of Susceptibility to Neurodegeneration in the Congo
Daniel Tshala Katumbay, Oregon Health Sciences University Exposure focus: nutrition |
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| 11:15 – 13:00 | Lunch and Poster Presentations | |
| 13:00 – 13:30 | Environmental Exposures and Infectious Disease | Indoor Residual Spraying for Malaria Control and Child Development in the South African VHEMBE birth cohort.
Jonathan Chevrier, McGill University, ISEE Africa Chapter Exposure focus: pesticides |
| 13:30 – 14:00 | Trace Elements and Risk of Severe Malaria and Neurodevelopmental Impairment
Chandy John, Indiana University Exposure focus: biomarkers of exposure and inflammation |
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| 14:00 – 14:15 | Break | |
14:15 – 16:45 |
Panel Discussion
Chairs: Mark Nicol, University of Cape Town Michele Ramsay, Wits University Panelists: Kiros Berhane, University of Southern California Brenda Eskenazi, University of California, Berkeley Adrie Steyn, Africa Health Research Institute |
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| 16:45 | Closing remarks: Gwen Collman, NIEHS | |
| 7:00 | Registration MH 1 Foyer | ||||||
| AD 11 (Break Out Room) | AD7 (Boardroom) | ||||||
| 8:00-8:45 | H3Africa Principal Investigators
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Independent Expert Committee (IEC) | |||||
| 8:45-9:30 | IEC & Funders | ||||||
| 9:30-9:45 | Tea/Coffee Poster Session MH 1 Foyer (15 min) | ||||||
| Working Group Session I | |||||||
| AD 7 | AD 10 | AD11 | AD1 | ||||
| 9:45-11:00 | Phenotype Harmonization
Chair: TBA
Rapporteur: Robin Mason & Karen Lacourciere |
Education & Coordinated Training WG
Chairs: Oumar Samassekou & Reginald Obiako
Rapporteur: Laura Povlich & Maria Giovanni |
Biorepository WG
Chair: Elizabeth Mayne
Rapporteur: Gabriel Batzli |
Environmental Health
Chairs: TBA
Rapporteur: Bonnie Joubert and Kimberly McAllister |
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| Plenary Session I
MH 1 Chair: Barry Bloom |
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| 11:00-12:50 | Genomic Medicine & Translational Research
Facilitators: Nicky Mulder & Jenniffer Maroa |
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| 12:50-13:50 | Lunch (Auditorium Club Level 1 KCC) & Poster Sessions MH1 Foyer (60 min) | ||||||
| H3Africa PI Presentations Session I
MH1 Chair: Rex Chisholm |
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| 13:50-14:10 | Project: H3Africa Administrative Coordinating Centre: Enabling and Supporting Genomics and Health Research Capacity Building in Africa
Title: H3ACC Updates Presenter & PI: Michelle Skelton Presentation: 15 min Q&A 5 min |
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| 14:10-14:30 | Project: Transgenerational Epigenomics of Trauma and PTSD in Rwanda
Presenter & PI: Leon Mutesa Presentation: 18 min Q&A 2 min |
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| 14:30-14:50 | Project: AWI-Gen Phase 2: Genomic and environmental risk factors for cardiometabolic disease in Africans
Title: Genetic and environmental contributions to cardiometabolic diseases and related traits in Africans: AWI-Gen coming to fruition Presenter & PI: Michele Ramsay Presentation: 18 min Q&A 2 min |
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| 14:50-15:10 | Project: Collaborative African Genomics Network (CAfGEN)
Title: Collaborative African Genomics Network (CAfGEN) Study Updates Presenter & PI: Mogomotsi Matshaba Presentation: 18 min Q&A 2min |
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| 15:10-15:30 | Project: H3ABioNet: a sustainable African Bioinformatics Network for H3Africa
Title: H3ABioNet resources for H3Africa Presenter & PI: Nicola Mulder Presentation: 18 min Q&A: 2 min |
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| 15:30-15:50 | Project: RHDGen: The Genetics of Rheumatic Heart Disease Network
Title: Tribute to Bongani Mayosi & Update from RHDGen Presenters: Mark Engel & Babu Muhamed PI: Bongani Mayosi Presentation: 18 min Q&A 2 min |
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| 15:50-16:05 | Tea & Poster Session MH1 Foyer (15 min) | ||||||
| H3Africa PI Presentations Session II
Biorepositories MH1 Chair: Rex Chisholm |
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| 16:05-16:30 | Project: Integrated Biorepository of H3Africa Uganda – IBRH3AU
PI: Moses Joloba |
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| Project: IHVN H3Africa Biorepository (I-HAB) Initiative
PI: Alash’le Abimiku |
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| Project: Establishment of an H3Africa Biorepository at Clinical Laboratory Services
PI: Elizabeth Mayne |
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| Working Group Session II | |||||||
| AD 7 | AD 10 | AD 11 | AD 1 | ||||
| 16:30-18:00 | Outreach & Communications
Chair: TBA
Rapporteurs: Barbara Sina & Deborah Ndlovu |
Genome Analysis/ GAPW Sub Group
Chairs: Zane Lombard; Adebowale Adeyemo & Neil Hanchard Rapporteur: Charles Rotimi & Gabriel Batzli
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HIV/AIDS
Chairs: Mogomotsi Matshaba & Francesc Xavier Gomez-Olive
Rapporteur: Sudha Srinivasan & Megan Hoffman |
Sustainability
Chairs; Raj Ramesar & Dwomoa Adu
Rapporteur: Jennifer Troyer, Mark Guyer & Audrey Duncanson |
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| Working Group Report Back Session I
MH1 Chair: Philip Awadalla |
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| Working Group | Presenter | ||||||
| 18:00-18:40 | Education & Coordinated Training | Oumar Samassekou | |||||
| Environmental Health | Gwen Collman | ||||||
| Biorepository | Elizabeth Mayne | ||||||
| Phenotype Harmonization | TBA | ||||||
| Discussion & Feedback | |||||||
| 19:00 | Drinks Reception (The Larder/Hotel Pool Area/Rooftop Bar KCC) TBC Weather Dependent | ||||||
| 19:30 | Dinner at Filini Restaurant | ||||||
| 8:00 | Registration MH 1 Foyer | ||||||||
| Working Group Session III | |||||||||
| AD 6 (Boardroom) | AD 7
(Boardroom) |
AD 10 | AD 11 | AD 1 | MH 1 | ||||
| 8:00-8:30 | Data & Biospecimen Access Committee (DBAC)
Chair: Akin Abayomi
Rapporteur: Jenniffer Maroa |
CVD
Chair: Akinlolu Ojo & Sally Adebamowo
Rapporteur: Jennifer Troyer |
Ethics & Community Engagement WG
Chair: Aminu Yakubu & Paulina Tindana
Rapporteur: Ebony Madden & Katherine Littler |
Study Coordinators
Chairs: Emmanuel Nasinghe & Keofentse Mathuba Rapporteur: Robin Mason & Karen Lacourciere |
Rare Disease
Chair: Zane Lombard
Rapporteur: Megan Hoffman |
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| 8:30-9:30 | DBAC WG
Chair: Nicola Mulder Rapporteur: Audrey Duncanson |
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| Plenary Session II
MH 1 Chairs: Raj Ramesar & Dwomoa Adu |
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| 9:30-11:00 | Sustainability & Outreach Mini Presentations/Panel Discussion
Glaudina Loots; Peter Goodhand; Hans Hagen; Isayvani Naicker |
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| 11:00-11:15 | Tea/Coffee Poster Session MH 1 Foyer (15 min) | ||||||||
| AD 10 | AD 11 | ||||||||
| 11:15-12:15 | Data Submission Session
Facilitator: Ayton Meintjes |
H3Africa PI & DBAC | |||||||
| Plenary Session III
MH 1 Chair: Philip Awadalla |
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| 12:15-13:15 | H3Africa Data & Biospecimen Catalogue
Presenters: Hocine Bendou & Nicola Mulder |
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| 13:15-14:15 | Lunch (Auditorium Club Level 1 KCC) (60 min) | ||||||||
| H3Africa PI Presentations Session III
MH1 Chair: Charmaine Royal |
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| 14:15-14:35 | Project: West African Sustainable Leadership and Innovation Training in Bioinformatics Research (WASLITBRE)
Presenter: Ezekiel Adebiyi PI: Ezekiel Adebiyi, Peter Amoako-Yirenky, Seydou Doumbia Presentation: 18 min Q&A: 2min |
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| 14:35-14:55 | Project: West African Center of Excellence for Global Health Bioinformatics Research Training
Title: “A Bioinformatics Training Program in Mali: Approach, Perspective, and Sustainability” Presenter: Jeffrey Shaffer PI: Seydou Doumbia, Jian Li, Jeffrey Shaffer Presentation: 13 min Q&A: 2min |
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| 14:55-15:15 | Project & Presentation Title: Nurturing Genomics and Bioinformatics Research Capacity in Africa (BRecA)
Presenter: Daudi Jjingo PI: David Kateete, Daudi JJingo, Irving Jordan, Graeme Mardon Presentation: 18 min Q&A: 2min |
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| 15:15-15:35 | Project: Eastern Africa Network for Bioinformatics Training
Presenter: Daniel Masiga PI: Daniel Masiga Presentation: 18 min Q&A: 2min |
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| 15:35-15:45 | Tea/Coffee Break (10 min) | ||||||||
| Plenary Session IV
MH1 Chair: Barry Bloom & Charmaine Royal |
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| 15:45-16:00 | FAIR Data
Presenter: Nicola Mulder |
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| Working Group Report Back Session II
MH1 Chair: Barry Bloom & Charmaine Royal |
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| Presenter | |||||||||
| 16:00 -17:00 | Ethics & CE WG | Aminu Yakubu & Paulina Tindana | |||||||
| Study Coordinators | Emmanuel Nasinghe | ||||||||
| Genome Analysis WG/GAPW Sub Group | Adebowale Adeyemo & Neil Hanchard | ||||||||
| Sustainability | Raj Ramesar | ||||||||
| Outreach & Communications | TBA | ||||||||
| CVD | Michele Ramsay | ||||||||
| HIV/AIDS | Mogomotsi Matshaba | ||||||||
| Rare Disease | Zane Lombard | ||||||||
| Discussion & IEC Feedback | |||||||||
| Closing by Steering Committee Chair: Nicola Mulder | |||||||||
| Tea available | |||||||||
| AD 11 | AD 1 | ||||||||
| 17:10-18:50 | H3Africa Steering Committee & IEC (18:30 DBAC Joins) | CRF
Facilitator: Katherine Johnson |
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| 19:00 | Drinks Reception KCC Main Foyer | ||||||||
| 19:30 | Formal Dinner MH 1
Tribute to Professor Bongani Mayosi by Professor Raj Ramesar
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| 7:30 | Registration |
| 9:00-11:00 | Opening Session |
| 10:00 | Plenary 1 Presenter: Eric Green (USA) |
| 10:50 | Tribute to Bongani Mayosi |
| 11:00-11:30 | Tea |
| 11:30-13:00 | Session 1 – African population genetics |
| 13:00-14:00 | Lunch and Poster viewing (Promega – short trade talk) |
| 14:00-15:30 | Session 2 – Bioinformatics Training and Young researchers |
| 15:30-16:00 | Tea |
| 16:00-17:30 | Session 3 – H3Africa Consortium Showcase |
| 17:30 – 18:45 | Panel Discussion: Sustainability of Genomics and Human Genetics in Africa |
| 19:00 | Opening Reception |
| 8:00 | Registration |
| 8:00 | Workshop: Challenges in publishing from Africa |
| 9:00-10:30 | Session 4 Part 1 – Epigenomics and Functional Genomics |
| 10:30-11:00 | Tea |
| 11:00-12:30 | Session 5 Part 2 – Epigenomics and Functional Genomics |
| 12:30-14:00 | Lunch Box and Open Forum: Establishing a ‘2020 Vision’ for Genomics |
| 14:00-15:30 | Session 6 – Host Genetics and Infectious Disease |
| 15:30-16:00 | Tea |
| 16:00 | Panel Discussion: Translational genomics |
| 17:00 | AGM |
| 19:00 | Gala Dinner |
| 8:00 | Registration |
| 8:00 | Workshop: Career opportunities for young African geneticists |
| 9:00-9:45 | Plenary 2 |
| 9:45-11:10 | Session 7 – Genomics of Rare Diseases |
| 11:10-11:40 | Tea |
| 11:40-12:55 | Session 8 – Ethics and Genomics in Africa |
| 12:55-14:00 | Lunch and Poster viewing |
| 14:00-16:00 | Session 9 – Complex Disease Genomics |
| 16:00 | Strategic planning for the AfSHG: Building skills and resources for genomics, epigenetics and bioinformatics research for Africa |
| 17:30 | AfSHG Committee Meeting |
| Session detail | Facilitator (s) | |
| 8.30 -9.00 (30 mins) | Welcome and intro
· Introduction/ workshop objectives · Getting to know each other exercise · Review workshop expectations |
Paulina Tindana/Lillian Mutengu |
| 9.00 – 9-30 (30 minutes) | Overview
· Types of engagement and related aims · H3Africa CE guidelines-Key highlights
|
Paulina Tindana/All
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| 9.30-11.30 (2 hours) | · Peer review and Group discussions on projects’ CE plans and needs
· Discussions |
All |
| COFFEE/TEA BREAK 11.30-12.00 (30mins) | ||
| 12.00 – 1.30 (1 hour 30 mins) | Evaluation of engagement methods
· Overview of evaluation methods and questions and discussion · Group exercise |
Dorcas Kamuya
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| LUNCH BREAK 13:30- 14:30 (1 hour) | ||
| 2.30 – 4.30 (2 hours)
|
CE Evaluation support needs
· Group work on developing/strengthening CE and Evaluation plans · Feedback |
Lillian Mutengu/Victoria Nembaware
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| 3.30-4.15 (45mins) | · CE and feedback of findings (sharing aggregate research findings | Paulina Tindana /Stuart Ali (AWIGen Experience) |
| 4.30-5.15 (45mins) | Brainstorm on proposed workplan for H3Africa CE activities
· How can consortium members support each other? · MESH platform · External support needed? · small groups discuss/plenary feedback · Next steps
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All
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| 5.15-5.30 | Brief evaluation and close | Jantina de Vries |
| 5.30 END | ||
| 7:30 | Dinner (Venue: TBA) | |